Protein detail
PANX1
Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)]
Entry name PANX1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 4 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)]
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Reproductive system diseases:Reproductive system diseases
- Potential drug targets
Transmembrane
41..61; Helical; 107..127; Helical; 218..238; Helical; 267..287; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
MRS1PX1UNQ2529
Gene Description
Pannexin 1
Chromosome
11
Position
94128841-94181968
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificlungBrain Regional Specificchoroid plexusCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (4)
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Reproductive system diseases:Reproductive system diseases
- Potential drug targets
Cellular Component (7)
Molecular Function (13)
- GO:0002020 protease binding
- GO:0005102 signaling receptor binding
- GO:0005198 structural molecule activity
- GO:0005253 monoatomic anion channel activity
- GO:0005262 calcium channel activity
- GO:0005347 ATP transmembrane transporter activity
- GO:0005515 protein binding
- GO:0022829 wide pore channel activity
- GO:0022840 leak channel activity
- GO:0042802 identical protein binding
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Biological Process (3)
Reactome (10)
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-112303 electric transmission across gap junctions
- R-hsa-9856530 high laminar flow shear stress activates signaling by piezo1 and pecam1 cdh5 kdr in endothelial cells
- R-hsa-622312 inflammasomes
- R-hsa-168249 innate immune system
- R-hsa-9856532 mechanical load activates signaling by piezo1 and integrins in osteocytes
- R-hsa-112316 neuronal system
- R-hsa-168643 nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways
- R-hsa-844456 the nlrp3 inflammasome
Canonical Pathways (3)
- M5887 Naba basement membranes
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence39
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PANX1 | SRC | P12931 | Y | 199 | phosphorylation | REACH_ProtMapperPhosphoSiteSparser_ProtMapperProtMapper | ProtMapper:26242575ProtMapper:30814251 |
| PANX1 | SRC | P12931 | Y | 309 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (32)
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | OmniPath | Yes | Yes | |||
| gap_junction | gap_junction | GO_Intercell | Yes | Yes | Yes | ||
| gap_junction | gap_junction | Ramilowski_location | Yes | Yes | Yes | ||
| pannexin | gap_junction | HGNC | Yes | Yes | Yes | ||
| gap_junction | gap_junction | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | OPM | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | PANX1 | Q96RD7 | Yes | Yes | Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:30814251ProtMapper:26242575ProtMapper:30814251SIGNOR:30814251 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARLNDEGS1PANX1 | O15121Q8WVX3Q96RD7 | 0:0:0 | hu.MAPhu.MAP2 | |||
| ARLNPANX1 | Q8WVX3Q96RD7 | 0:0 | hu.MAP | |||
| PANX1 | Q96RD7 | 7 | PDB | PDB:7wsvPDB:8gtsPDB:7f8jPDB:6m02PDB:7dwbPDB:6wbfPDB:8gttPDB:8gyoPDB:6wbkPDB:6v6dPDB:6ltoPDB:6m66PDB:6wbmPDB:6ltnPDB:6wbgPDB:7f8nPDB:6m67PDB:6wbnPDB:6wblPDB:7f8oPDB:6m68PDB:6wbi |
Sequence, Structure & Domains
Sequences
Length
426
Mass
48,050
Sequence
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96RD7-1; Sequence=Displayed; Name=2; IsoId=Q96RD7-2; Sequence=VSP_011476
Alternative Sequence
401..404; Missing (in isoform 2)
3D Structural Models
Turn
56..58; 91..93; 168..171; 355..357; 384..395; 412..414
Helix
3..10; 13..15; 33..53; 60..62; 74..87; 97..99; 100..107; 109..130; 132..161; 195..203; 208..235; 239..242; 251..253; 270..295; 297..300; 305..311; 327..338; 339..341; 343..354; 362..369; 396..398; 415..421
Beta Strand
21..27; 63..65; 88..90; 175..177; 204..206; 243..246; 257..259; 263..267; 312..315; 323..326; 373..376
3D Structure
Electron microscopy (22)
Domain & Motif Annotations
Compositional Bias
405..414; Polar residues; 415..426; Basic and acidic residues
Region
405..426; Disordered
Protein Families
Pannexin family
Sequence Similarities
Belongs to the pannexin family.
Clinical Relevance
Disease Involvement
Disease variant
Antibody