Protein detail
PAR4
Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
Entry name PAR4 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 7 | Transmembrane count 7 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
Protein Function (2)
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
83..103; Helical; Name=1; 109..129; Helical; Name=2; 152..172; Helical; Name=3; 193..213; Helical; Name=4; 248..268; Helical; Name=5; 284..304; Helical; Name=6; 320..343; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
7
EVMP confidence score
0.63
Fluorescence & Localization
Cell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificnon-classical monocyte
Function & Pathway
Protein Function (2)
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (5)
Reactome (8)
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-109582 hemostasis
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-372790 signaling by gpcr
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence67
Ligand-Receptor Signaling (52)
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| rhodopsin | receptor | Almen2009 | Yes | Yes | |||
| gpcr | receptor | UniProt_keyword | Yes | Yes | |||
| seven_transmembrane_7tm | receptor | HPMR | Yes | Yes | |||
| 7tm_a | receptor | HPMR | Yes | Yes | |||
| proteinase_activated_thrombin_7tm_a | receptor | HPMR | Yes | Yes | |||
| rhodopsin | receptor | Surfaceome | Yes | Yes | |||
| gpcr | receptor | Surfaceome | Yes | Yes | |||
| class_a_rhodopsin | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_peptide | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_peptide_proteinase_activated | receptor | GPCRdb | Yes | Yes |
Regulatory Interaction Network (14)
14 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PAR4 | Q96RI0 | GNAL | P38405 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| THRB | P00734 | PAR4 | Q96RI0 | Yes | Yes | iTALKSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | HINT:12732212connectomeDB2020:12732212Cellinker:12732212HPRD:12732212CellTalkDB:12732212LRdb:12732212Baccin2019:1273221212732210SIGNOR:22318735 | |
| PAR4 | Q96RI0 | GNAO | P09471 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| PAR4 | Q96RI0 | GNA12 | Q03113 | Yes | Yes | WangSIGNOR | SIGNOR:22318735 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 34265469 |
Sequence, Structure & Domains
Sequences
Length
385
Mass
41,133
Sequence
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
3D Structural Models
Beta Strand
44..46
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Region
21..42; Disordered; 362..385; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Drugs (3)
Supporting Publications7
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No related sentences available |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No related sentences available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |