Protein detail
PAR4
Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
Protein symbol PAR4 | UniProt ID | EVMP score 0.63 |
Frequency 7 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
Protein Function
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
83..103; Helical; Name=1; 109..129; Helical; Name=2; 152..172; Helical; Name=3; 193..213; Helical; Name=4; 248..268; Helical; Name=5; 284..304; Helical; Name=6; 320..343; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
7
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificnon-classical monocyte
Function & Pathway
Protein Function
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-109582 hemostasis
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-372790 signaling by gpcr
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
Regulatory Interaction Network
14 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PAR4 | Q96RI0 | GNA13 | Q14344 | Yes | Yes | No | WangSIGNOR | SIGNOR:22318735 |
| PAR4 | Q96RI0 | GNAI1 | P63096 | Yes | Yes | No | WangSIGNOR | SIGNOR:17158345SIGNOR:31160049 |
| PAR4 | Q96RI0 | GNAQ | P50148 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| PAR4 | Q96RI0 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR4 | Q96RI0 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| PAR4 | Q96RI0 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR4 | Q96RI0 | GNAS3 | O95467 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR4 | Q96RI0 | ALEX | P84996 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR4 | Q96RI0 | GNAS2 | P63092 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR4 | Q96RI0 | GNAS1 | Q5JWF2 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 34265469 |
Sequence, Structure & Domains
Sequences
Length
385
Mass
41,133
Sequence
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
3D Structural Models
Beta Strand
44..46
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Region
21..42; Disordered; 362..385; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.