Protein detail
KCNA7
Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7)
Entry name KCNA7 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 6 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7)
Protein Function (2)
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
- FDA approved drug targets:Small molecule drugs
Transmembrane
144..164; Helical; Name=Segment S1; 209..229; Helical; Name=Segment S2; 241..261; Helical; Name=Segment S3; 276..295; Helical; Voltage-sensor; Name=Segment S4; 312..332; Helical; Name=Segment S5; 373..393; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificCardiomyocytes
Function & Pathway
Protein Function (2)
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
- FDA approved drug targets:Small molecule drugs
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence16
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| ion_channel | ion_channel | DGIdb | Yes | ||||
| voltage_gated_potassium | ion_channel | HGNC | Yes | ||||
| ion_channel | ion_channel | HGNC | Yes | ||||
| ion_channel | ion_channel | Almen2009 | Yes | ||||
| potassium | ion_channel | Almen2009 | Yes | ||||
| voltage_gated | ion_channel | Almen2009 | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| ion_channel | ion_channel | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location |
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Sequence, Structure & Domains
Sequences
Length
456
Mass
50,559
Sequence
MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAPPGKHLVTEV
Domain & Motif Annotations
Motif
358..363; Selectivity filter
Domain (CC)
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.; DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Protein Families (3)
- Potassium channel family
- A (Shaker) (TC 1.A.1.2) subfamily
- Kv1.7/KCNA7 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |