EV MemProt Atlas

Basic Information11

Protein Names

Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000112851

Entrez Gene Symbol

ERBIN

Gene Synonym (2)

ERBB2IPLAP2

Gene Description

Erbb2 interacting protein

Chromosome

5

Position

65883128-66082546

Supporting publications (n)

1

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (13)

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Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (16)

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Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence27

Enzyme-Mediated Modification (6)

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ERBIN	ATM	Q13315	S	1,271	phosphorylation	KEA	KEA:17570479
ERBIN	CDK1	P06493	S	857	phosphorylation	KEA	KEA:17570479
ERBIN	ITK	Q08881	Y	972	phosphorylation	KEA	KEA:17570479
ERBIN	MAPK8	P45983	S	857	phosphorylation	KEA	KEA:17570479
ERBIN	PRKCA	P17252	T	917	phosphorylation	KEA	KEA:17570479
ERBIN	PRKDC	P78527	S	1,271	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
basolateral_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ERBIN	Q96RT1	SMAD3	P84022	Yes	Yes	No	WangNetPathHPRDCui2007HINTSignaLink3InnateDBSPIKE_LCSPIKE	SignaLink3:12650946 SPIKE:12650946 HPRD:12650946 SignaLink3:18003620 HINT:12650946 InnateDB:18729074 NetPath:12650946 SignaLink3:23331499 SignaLink3:17591701 InnateDB:17591701 HINT:17591701 SPIKE_LC:12650946
ERBIN	Q96RT1	SMAD2	Q15796	Yes	Yes	Yes	WangNetPathHPRDCui2007HINTSignaLink3InnateDBSPIKE_LCSPIKE	SignaLink3:12650946 SPIKE:12650946 HPRD:12650946 SignaLink3:18003620 HINT:12650946 InnateDB:18729074 NetPath:12650946 SignaLink3:23331499 SignaLink3:17591701 InnateDB:17591701 HINT:17591701 SPIKE_LC:12650946
ARVC	O00192	ERBIN	Q96RT1	Yes	Yes	No	SIGNORELMHINTHPRDInnateDBLit-BM-17	ELM:22087225 HPRD:11821434 Lit-BM-17:11821434 ELM:24550280 HINT:24550280 Lit-BM-17:24550280 SIGNOR:11821434 ELM:22889411 HINT:11821434 ELM:11821434 HINT:15123239 InnateDB:15123239
CTND2	Q9UQB3	ERBIN	Q96RT1	Yes	Yes	No	ELMSIGNORHPRD	HPRD:11821434 ELM:24550280 SIGNOR:11821434 ELM:22889411 ELM:11821434 ELM:11729199 ELM:10896674

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GST-Smad2	ARID1B CREBBP ERBIN NCOA3 SMARCA4 SMARCC1 SMARCC2 TRIM33	P51532 Q8NFD5 Q8TAQ2 Q92793 Q92922 Q96RT1 Q9UPN9 Q9Y6Q9	1:1:1:1:1:1:1:1	Compleat	Compleat:HC2483	18003620
GST-Smad3	ARID1B CREBBP ERBIN NCOA3 NCOR1 NCOR2 SMARCA4 SMARCC1 SMARCC2 TRIM33	O75376 P51532 Q8NFD5 Q8TAQ2 Q92793 Q92922 Q96RT1 Q9UPN9 Q9Y618 Q9Y6Q9	1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1777	18003620
	CNOT1 CNOT2 CNOT3 CNOT7 CSNK2A1 ERBIN	A5YKK6 O75175 P68400 Q96RT1 Q9NZN8 Q9UIV1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9587
	AZU1 ERBIN	P20160 Q96RT1	0:0	hu.MAP2
	ERBIN	Q96RT1	2	PDB	PDB:6q0uPDB:6q0mPDB:6q0nPDB:2h3lPDB:6ubh

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains15

Sequences

Length

1,412

Mass

158,298

Sequence

MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS

Alternative Products

Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q96RT1-1; Sequence=Displayed; Name=2; IsoId=Q96RT1-2; Sequence=VSP_010802; Name=3; IsoId=Q96RT1-3; Sequence=VSP_010802, VSP_010804; Name=4; IsoId=Q96RT1-4; Sequence=VSP_010802, VSP_010807; Name=5; IsoId=Q96RT1-5; Sequence=VSP_010802, VSP_010803; Name=6; IsoId=Q96RT1-6; Sequence=VSP_010802, VSP_010806; Name=7; IsoId=Q96RT1-7; Sequence=VSP_010802, VSP_010803, VSP_010804, VSP_010805; Name=8; IsoId=Q96RT1-8; Sequence=VSP_044536; Name=9; IsoId=Q96RT1-9; Sequence=VSP_047389, VSP_010802

Alternative Sequence

531..534; Missing (in isoform 9); 1212..1252; Missing (in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 9); 1212..1252; KHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMK -> SMLSRSFNSNFTTVSSFHCGSSRDLHGSQGSLALSVADRRGSGGHIFR (in isoform 8); 1253..1267; Missing (in isoform 5 and isoform 7); 1268..1278; Missing (in isoform 3 and isoform 7); 1279..1321; Missing (in isoform 7); 1322..1352; Missing (in isoform 6); 1353..1377; Missing (in isoform 4)

3D Structural Models

Turn

1339..1342; 1364..1368

Helix

1388..1397

Beta Strand

1318..1327; 1329..1331; 1333..1338; 1346..1348; 1353..1359; 1374..1378; 1400..1410

3D Structure

NMR spectroscopy (1); X-ray crystallography (10)

Domain & Motif Annotations

Compositional Bias

470..480; Basic and acidic residues; 506..532; Basic and acidic residues; 533..542; Low complexity; 632..641; Basic and acidic residues; 650..662; Low complexity; 663..681; Polar residues; 817..835; Polar residues; 1075..1086; Polar residues; 1157..1171; Polar residues

Repeat

23..44; LRR 1; 47..68; LRR 2; 70..91; LRR 3; 93..114; LRR 4; 116..137; LRR 5; 139..161; LRR 6; 162..183; LRR 7; 185..206; LRR 8; 208..229; LRR 9; 231..252; LRR 10; 254..275; LRR 11; 277..298; LRR 12; 300..321; LRR 13; 323..344; LRR 14; 346..367; LRR 15; 369..391; LRR 16; 392..413; LRR 17

Domain (FT)

1321..1410; PDZ

Region

464..489; Disordered; 506..542; Disordered; 615..681; Disordered; 803..867; Disordered; 997..1021; Disordered; 1075..1192; Disordered

Protein Families

LAP (LRR and PDZ) protein family

Sequence Similarities

Belongs to the LAP (LRR and PDZ) protein family.

Clinical Relevance4

Antibody (2)

HPA048606 HPA059863

Interaction Protein (3)

ENSG00000108953ENSG00000144283ENSG00000164924

Interaction Count

3

Interaction Dataset (2)

biogrid_opencellintact_biogrid

Supporting Publications1

PMID	Title	Abstract
37713494	ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.	No abstract available

Entry name ERBIN	UniProt ID Q96RT1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins