Protein detail
FNBP1
Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)
Protein symbol FNBP1 | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count | Protein classification Disease related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)
Protein Class
Disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FBP17KIAA0554
Gene Description
Formin binding protein 1
Chromosome
9
Position
129887187-130043189
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificNK-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-199991 membrane trafficking
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696270 rnd2 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways
- M184 Pid ecadherin keratinocyte pathway
- M266 Pid ncadherin pathway
- M156 Pid ecadherin nascent aj pathway
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| fbar_actin_dynamics_endocytosis | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| BTF3CNOT1CNOT2CNOT3CNOT4CNOT6CNOT6LCNOT7CNOT8FDXRFNBP1LHNRNPA1UBC | A5YKK6O75175O95628P09651P0CG48P20290P22570Q5T0N5Q96LI5Q9NZN8Q9UFF9Q9UIV1Q9ULM6 | 1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9481 | ||
| AZI2BBOX1CASP2FNBP1LGBA1HNRNPKRNASET2SNX33TANK | O00584O75936P04062P42575P61978Q5T0N5Q8WV41Q92844Q9H6S1 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| CDC42DAAM1FNBP1FNBP1LSGSM2TRIP10UBC | O43147P0CG48P60953Q15642Q5T0N5Q96RU3Q9Y4D1 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8110 | ||
| ACP1CDC42DAAM1FNBP1FNBP1LTRIP10UBC | P0CG48P24666P60953Q15642Q5T0N5Q96RU3Q9Y4D1 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8977 | ||
| FNBP1LMAPRE2 | Q15555Q5T0N5 | 0:0 | hu.MAP | |||
| ARHGAP44FNBP1L | Q17R89Q5T0N5 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 40326690 |
Sequence, Structure & Domains
Sequences
Length
617
Mass
71,307
Sequence
MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVCLDKNAKDS
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96RU3-1; Sequence=Displayed; Name=2; IsoId=Q96RU3-2; Sequence=VSP_021695, VSP_021696; Name=3; IsoId=Q96RU3-3; Sequence=VSP_021694, VSP_021696; Name=4; IsoId=Q96RU3-4; Sequence=VSP_021693; Name=5; IsoId=Q96RU3-5; Sequence=VSP_021695
Alternative Sequence
329..394; Missing (in isoform 4); 330..358; Missing (in isoform 3); 391..395; Missing (in isoform 2 and isoform 5); 616..617; DS -> GAKTYI (in isoform 2 and isoform 3)
3D Structural Models
Turn
7..9
Helix
3..6; 11..52; 68..160; 166..206; 208..238; 241..257; 261..272
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
338..347; Pro residues; 499..512; Polar residues
Coiled Coil
67..259; 398..490
Domain (CC)
The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.
Domain (FT)
1..264; F-BAR; 404..481; REM-1; 550..611; SH3
Region
1..335; Interaction with microtubules; 1..79; Required for self-association and induction of membrane tubulation; 251..617; Required for self-association and induction of membrane tubulation; 280..315; Disordered; 333..366; Disordered; 400..552; Interaction with RND2; 486..531; Disordered; 495..617; Interaction with PDE6G; 514..617; Required for interaction with TNKS; 535..617; Interaction with DNM1 and DNM3; 550..617; Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2; 553..610; Interaction with FASLG; 553..609; Interaction with DNM2 and WASL
Protein Families
FNBP1 family
Sequence Similarities
Belongs to the FNBP1 family.