Protein detail

FNBP1

Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)

Entry name FNBP1	UniProt ID Q96RU3	EVMP confidence score 0.63
Supporting publications (n) 9	Transmembrane count	Protein classification Disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)

Protein Class (3)

Disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000187239

Entrez Gene Symbol

FNBP1

Gene Synonym (2)

FBP17KIAA0554

Gene Description

Formin binding protein 1

Chromosome

Position

129887187-130043189

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization6

Tissue Specificbone marrowCell SpecificNK-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells

Function & Pathway8

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (8)

Molecular Function (3)

Biological Process (3)

KEGG

hsa05131 Shigellosis

Reactome (9)

Canonical Pathways (3)

M184 Pid ecadherin keratinocyte pathway
M266 Pid ncadherin pathway
M156 Pid ecadherin nascent aj pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence15

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
fbar_actin_dynamics_endocytosis	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BTF3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 FDXR FNBP1L HNRNPA1 UBC	A5YKK6 O75175 O95628 P09651 P0CG48 P20290 P22570 Q5T0N5 Q96LI5 Q9NZN8 Q9UFF9 Q9UIV1 Q9ULM6	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9481
AZI2 BBOX1 CASP2 FNBP1L GBA1 HNRNPK RNASET2 SNX33 TANK	O00584 O75936 P04062 P42575 P61978 Q5T0N5 Q8WV41 Q92844 Q9H6S1	0:0:0:0:0:0:0:0:0	hu.MAP2
CDC42 DAAM1 FNBP1 FNBP1L SGSM2 TRIP10 UBC	O43147 P0CG48 P60953 Q15642 Q5T0N5 Q96RU3 Q9Y4D1	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8110
ACP1 CDC42 DAAM1 FNBP1 FNBP1L TRIP10 UBC	P0CG48 P24666 P60953 Q15642 Q5T0N5 Q96RU3 Q9Y4D1	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8977
FNBP1L MAPRE2	Q15555 Q5T0N5	0:0	hu.MAP
ARHGAP44 FNBP1L	Q17R89 Q5T0N5	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	40326690

Sequence, Structure & Domains15

Sequences

Length

617

Mass

71,307

Sequence

MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVCLDKNAKDS

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96RU3-1; Sequence=Displayed; Name=2; IsoId=Q96RU3-2; Sequence=VSP_021695, VSP_021696; Name=3; IsoId=Q96RU3-3; Sequence=VSP_021694, VSP_021696; Name=4; IsoId=Q96RU3-4; Sequence=VSP_021693; Name=5; IsoId=Q96RU3-5; Sequence=VSP_021695

Alternative Sequence

329..394; Missing (in isoform 4); 330..358; Missing (in isoform 3); 391..395; Missing (in isoform 2 and isoform 5); 616..617; DS -> GAKTYI (in isoform 2 and isoform 3)

3D Structural Models

Turn

7..9

Helix

3..6; 11..52; 68..160; 166..206; 208..238; 241..257; 261..272

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

338..347; Pro residues; 499..512; Polar residues

Coiled Coil

67..259; 398..490

Domain (CC)

The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.

Domain (FT)

1..264; F-BAR; 404..481; REM-1; 550..611; SH3

Region

1..335; Interaction with microtubules; 1..79; Required for self-association and induction of membrane tubulation; 251..617; Required for self-association and induction of membrane tubulation; 280..315; Disordered; 333..366; Disordered; 400..552; Interaction with RND2; 486..531; Disordered; 495..617; Interaction with PDE6G; 514..617; Required for interaction with TNKS; 535..617; Interaction with DNM1 and DNM3; 550..617; Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2; 553..610; Interaction with FASLG; 553..609; Interaction with DNM2 and WASL

Protein Families

FNBP1 family

Sequence Similarities

Belongs to the FNBP1 family.

Clinical Relevance4

Antibody (4)

HPA019635 HPA019691 HPA022119 HPA067742

Interaction Protein (6)

ENSG00000079805ENSG00000106976ENSG00000117560ENSG00000137942ENSG00000173273ENSG00000205302

Interaction Count

Interaction Dataset (2)

intact_biogridintact_biogrid_opencell

Supporting Publications9

PMID	Title	Abstract
29242380	Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers.	No abstract available
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
37862381	Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40311616	Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer.	No abstract available
40619995	A 96-Well Ultrafiltration Approach for the High-Throughput Proteome Analysis of Extracellular Vesicles Isolated From Conditioned Medium.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available