Protein detail
TRIB1
Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
Entry name TRIB1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization2
Cell SpecificNeutrophil progenitors
Function & Pathway6
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Cellular Component (3)
Molecular Function (6)
- GO:0004860 protein kinase inhibitor activity
- GO:0005515 protein binding
- GO:0031434 mitogen-activated protein kinase kinase binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0055106 ubiquitin-protein transferase regulator activity
- GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process (3)
Reactome (4)
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence12
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ASH2LCTBP1DIDO1DPY30H3-4H3C11KMT2AKMT2BRBBP5SETD1ASMAP2TRIB1UBCWDR5WDR82 | O15047P0CG48P61964P68431Q03164Q13363Q15291Q16695Q6UXN9Q8WU79Q96RU8Q9BTC0Q9C005Q9UBL3Q9UMN6 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4262 | ||
| COP1DET1ETS2ETV1ETV5FAM120BFOSMALT1STK40TRIB1TRIB2 | P01100P15036P41161P50549Q7L5Y6Q8N2I9Q8NHY2Q92519Q96EK7Q96RU8Q9UDY8 | 0:0:0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| COP1DET1ETS2ETV1ETV5MALT1STK40TRIB1TRIB2 | P15036P41161P50549Q7L5Y6Q8N2I9Q8NHY2Q92519Q96RU8Q9UDY8 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| STK40TRIB1 | Q8N2I9Q96RU8 | 0:0 | hu.MAP | |||
| COP1TRIB1 | Q8NHY2Q96RU8 | 6:6 | PDB | PDB:5igq |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40222457 |
Sequence, Structure & Domains16
Sequences
Length
372
Mass
41,009
Sequence
MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96RU8-1; Sequence=Displayed; Name=2; IsoId=Q96RU8-2; Sequence=VSP_054894
Alternative Sequence
1..166; Missing (in isoform 2)
3D Structural Models
Turn
111..113; 141..143
Helix
124..130; 132..135; 167..174; 179..198; 208..210; 246..248; 251..254; 262..279; 289..297; 309..318; 323..325; 329..332; 336..341
Beta Strand
89..91; 94..98; 103..110; 116..123; 137..139; 146..151; 153..160; 211..215; 221..223; 240..243; 305..307; 360..362
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
59..75; Pro residues
Motif
355..360; COP1-binding
Domain (CC)
The protein kinase active site is incompatible with ATP binding and is inactive (PubMed:26455797).; DOMAIN: The C-terminus (351-372) is required for interaction with COP1 (PubMed:27041596).; DOMAIN: The COP1-binding motif (355-360) is required for regulation activity (By similarity).
Domain (FT)
91..338; Protein kinase
Region
1..23; Disordered; 52..86; Disordered
Protein Families (3)
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- Tribbles subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Clinical Relevance3
Interaction Protein (2)
ENSG00000140543ENSG00000196182
Interaction Count
2
Interaction Dataset (2)
biogrid_bioplexintact_biogrid