Protein detail

HPLN3

Hyaluronan and proteoglycan link protein 3

Entry name HPLN3	UniProt ID Q96S86	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Hyaluronan and proteoglycan link protein 3

Protein Class (2)

Predicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000140511

Entrez Gene Symbol

HAPLN3

Gene Synonym (2)

EXLD1HsT19883

Gene Description

Hyaluronan and proteoglycan link protein 3

Chromosome

Position

88877294-88895597

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway5

Protein Function

Predicted secreted proteins

Cellular Component (3)

Molecular Function

GO:0005540 hyaluronic acid binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence15

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	UniProt_location	Yes	No	Yes	No	No
ecm	ecm	CellCellInteractions	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HAPLN3 SUSD4	Q5VX71 Q96S86	0:0	hu.MAP
	CHAC2 HAPLN3	Q8WUX2 Q96S86	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	27863537 32944193

Sequence, Structure & Domains6

Sequences

Length

360

Mass

40,894

Sequence

MGLLLLVPLLLLPGSYGLPFYNGFYYSNSANDQNLGNGHGKDLLNGVKLVVETPEETLFTYQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVHLRQDKEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAPGVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPDPQSRLYGVYCYRQH

Domain & Motif Annotations

Domain (FT)

48..164; Ig-like V-type; 166..261; Link 1; 266..358; Link 2

Protein Families

HAPLN family

Sequence Similarities

Belongs to the HAPLN family.

Clinical Relevance1

Antibody

HPA039237

Supporting Publications1

PMID	Title	Abstract
40326690	Rapid Identification of Esophageal Squamous Cell Carcinoma Biomarkers by MALDI-TOF MS Fingerprinting of Extracellular Vesicles.	No abstract available