Protein detail
PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)
Entry name PP16B | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ANKRD4KIAA0823TIMAP
Gene Description
Protein phosphatase 1 regulatory subunit 16B
Chromosome
20
Position
38805697-38923024
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueBrain Regional Specificcerebral cortexCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PPP1R16B | PLK4 | O00444 | S | 69 | phosphorylation | PhosphoSite | |
| PPP1R16B | PRKCA | P17252 | S | 331 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PPP1R16B | GSK3B | P49841 | S | 333 | phosphorylation | KEA | KEA:17609201 |
| PPP1R16B | GSK3B | P49841 | S | 337 | phosphorylation | KEA | KEA:17609201 |
| PPP1R16B | PPP1CA | P62136 | S | 333 | phosphorylation | KEA | KEA:17609201 |
| PPP1R16B | PPP1CA | P62136 | S | 337 | phosphorylation | KEA | KEA:17609201 |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | PP16B | Q96T49 | Yes | No | Yes | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:27939168SIGNOR:27939168 |
| PLK4 | O00444 | PP16B | Q96T49 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:34343028 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry；Western blotting；Immunoelectron Microscopy | 1 | 39940923 |
Sequence, Structure & Domains
Sequences
Length
567
Mass
63,551
Sequence
MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGELDMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPIEEMEEKVHGCCRIS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96T49-1; Sequence=Displayed; Name=2; IsoId=Q96T49-2; Sequence=VSP_047508
Alternative Sequence
233..274; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
385..403; Basic and acidic residues; 504..515; Polar residues
Repeat
100..129; ANK 1; 133..162; ANK 2; 228..257; ANK 3; 261..290; ANK 4; 530..559; ANK 5
Coiled Coil
15..55
Region
378..403; Disordered; 504..525; Disordered