Protein detail
SCN2A
Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)
Protein symbol SCN2A | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 24 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
Basic Information
Protein Names
Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Human disease related genes:Nervous system diseases:Epilepsy
- Voltage-gated ion channels:Voltage-Gated Sodium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
130..148; Helical; Name=S1 of repeat I; 156..176; Helical; Name=S2 of repeat I; 191..208; Helical; Name=S3 of repeat I; 215..231; Helical; Name=S4 of repeat I; 251..270; Helical; Name=S5 of repeat I; 402..422; Helical; Name=S6 of repeat I; 760..778; Helical; Name=S1 of repeat II; 790..809; Helical; Name=S2 of repeat II; 824..843; Helical; Name=S3 of repeat II; 846..863; Helical; Name=S4 of repeat II; 880..898; Helical; Name=S5 of repeat II; 962..982; Helical; Name=S6 of repeat II; 1210..1227; Helical; Name=S1 of repeat III; 1241..1259; Helical; Name=S2 of repeat III; 1274..1292; Helical; Name=S3 of repeat III; 1301..1319; Helical; Name=S4 of repeat III; 1337..1356; Helical; Name=S5 of repeat III; 1448..1469; Helical; Name=S6 of repeat III; 1533..1550; Helical; Name=S1 of repeat IV; 1562..1580; Helical; Name=S2 of repeat IV; 1593..1610; Helical; Name=S3 of repeat IV; 1624..1640; Helical; Name=S4 of repeat IV; 1660..1677; Helical; Name=S5 of repeat IV; 1753..1775; Helical; Name=S6 of repeat IV
Transmembrane Count
24
Ensembl
Entrez Gene Symbol
Gene Synonym
HBSCIHBSCIINav1.2SCN2A1SCN2A2
Gene Description
Sodium voltage-gated channel alpha subunit 2
Chromosome
2
Position
165194993-165392310
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificprostateCell SpecificHematopoietic stem cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Human disease related genes:Nervous system diseases:Epilepsy
- Voltage-gated ion channels:Voltage-Gated Sodium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SCN2A | PRKCA | P17252 | S | 687 | phosphorylation | KEA | KEA:17570479 |
| SCN2A | PRKCB | P05771 | S | 1,506 | phosphorylation | KEA | KEA:17570479 |
| SCN2A | RPS6KA3 | P51812 | S | 573 | phosphorylation | KEA | KEA:17570479 |
| SCN2A | RPS6KA3 | P51812 | S | 610 | phosphorylation | KEA | KEA:17570479 |
| SCN2A | RPS6KA3 | P51812 | S | 623 | phosphorylation | KEA | KEA:17570479 |
| SCN2A | RPS6KA3 | P51812 | S | 687 | phosphorylation | KEA | KEA:17570479 |
| SCN2A | SGK1 | O00141 | S | 687 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| channels | transporter | Surfaceome | No | Yes | No | No | No |
| sodiumchannels | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| voltage_gated_sodium | ion_channel | HGNC | No | Yes | No | No | No |
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Regulatory Interaction Network
10 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK2B | P67870 | SCN2A | Q99250 | Yes | Yes | No | SIGNOR | SIGNOR:19064667 |
| CSK21 | P68400 | SCN2A | Q99250 | Yes | Yes | No | SIGNOR | SIGNOR:19064667 |
| FGF14 | Q92915 | SCN2A | Q99250 | Yes | No | Yes | SIGNOR | SIGNOR:20679355 |
| FGF13 | Q92913 | SCN2A | Q99250 | Yes | No | Yes | HINTSIGNOR | HINT:36950384SIGNOR:20679355HINT:25232683 |
| CSK22 | P19784 | SCN2A | Q99250 | Yes | Yes | No | SIGNOR | SIGNOR:19064667 |
| CSK23 | Q8NEV1 | SCN2A | Q99250 | Yes | Yes | No | SIGNOR | SIGNOR:19064667 |
| NED4L | Q96PU5 | SCN2A | Q99250 | Yes | No | Yes | SIGNOR | SIGNOR:23778145 |
| GSK3B | P49841 | SCN2A | Q99250 | Yes | No | Yes | SIGNOR | SIGNOR:32599005 |
| FGF11 | Q92914 | SCN2A | Q99250 | Yes | No | Yes | SIGNOR | SIGNOR:20679355 |
| FGF12 | P61328 | SCN2A | Q99250 | Yes | No | Yes | SIGNOR | SIGNOR:20679355 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
2,005
Mass
227,975
Sequence
MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Adult, 6A; IsoId=Q99250-1; Sequence=Displayed; Name=2; Synonyms=Neonatal, 6N; IsoId=Q99250-2; Sequence=VSP_001032
Alternative Sequence
209; D -> N (in isoform 2)
3D Structural Models
Turn
317..319; 361..364; 412..414; 760..762; 785..787; 879..881; 939..941; 1192..1194; 1317..1319; 1369..1371; 1377..1379; 1391..1393; 1443..1446; 1460..1462; 1497..1500; 1711..1715; 1721..1723; 1728..1730; 1815..1817; 1827..1829; 1848..1850
Helix
118..121; 124..127; 129..145; 156..174; 190..202; 204..206; 218..226; 227..230; 234..245; 246..249; 251..269; 273..275; 370..381; 386..396; 399..401; 402..411; 415..440; 742..753; 763..777; 788..807; 823..840; 847..862; 865..878; 882..902; 904..909; 928..938; 944..954; 956..985; 1114..1116; 1195..1205; 1208..1223; 1224..1227; 1232..1235; 1239..1264; 1266..1269; 1273..1294; 1302..1305; 1306..1316; 1321..1330; 1331..1333; 1334..1358; 1383..1390; 1409..1420; 1424..1432; 1447..1449; 1450..1459; 1463..1482; 1492..1496; 1501..1505; 1520..1528; 1531..1549; 1557..1584; 1593..1615; 1622..1628; 1629..1633; 1636..1641; 1646..1654; 1657..1681; 1700..1710; 1716..1720; 1749..1784; 1792..1805; 1818..1823; 1836..1839; 1854..1866; 1870..1886; 1900..1926
Beta Strand
207..210; 276..280; 323..326; 329..331; 351..355; 367..369; 754..759; 810..813; 914..919; 1236..1238; 1360..1363; 1365..1367; 1397..1399; 1402..1408; 1682..1685; 1693..1699; 1811..1814; 1845..1847; 1851..1853
3D Structure
Electron microscopy (1); NMR spectroscopy (2); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
511..529; Basic and acidic residues; 596..610; Basic and acidic residues; 1155..1165; Acidic residues; 1935..1964; Basic and acidic residues; 1979..2005; Basic and acidic residues
Repeat
111..456; I; 741..1013; II; 1190..1504; III; 1513..1811; IV
Domain (CC)
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Domain (FT)
1905..1934; IQ
Region
28..61; Disordered; 494..529; Disordered; 590..610; Disordered; 917..918; Binds SCN2B; 1120..1165; Disordered; 1935..2005; Disordered
Protein Families
- Sodium channel (TC 1.A.1.10) family
- Nav1.2/SCN2A subfamily
Sequence Similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily.
Clinical Relevance
Disease Involvement
Disease variantEpilepsyFDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
TOCAINIDE HYDROCHLORIDEMEPHENYTOINTETRACAINENERISPIRDINERALFINAMIDEFOSPHENYTOINETIDOCAINE HYDROCHLORIDEINDECAINIDE HYDROCHLORIDELAMOTRIGINEPROPAFENONE HYDROCHLORIDEFOSPROPOFOLDISOPYRAMIDE PHOSPHATEDRONEDARONE HYDROCHLORIDEETHOTOINQUINIDINE SULFATEZONISAMIDECHLOROPROCAINESAFINAMIDEEVENAMIDEPROPOXYCAINE HYDROCHLORIDEPROPARACAINE HYDROCHLORIDEESLICARBAZEPINE ACETATECENOBAMATEPROCAINE HYDROCHLORIDERUFINAMIDEMEPIVACAINE HYDROCHLORIDEPHENYTOIN SODIUMIRAMPANELMERETHOXYLLINE PROCAINEPROPOFOLTOPIRAMATEQUINIDINE GLUCONATEPRILOCAINELIDOCAINEESLICARBAZEPINEPROCAINAMIDE HYDROCHLORIDEORPHENADRINE CITRATEDYCLONINE HYDROCHLORIDERILUZOLECOCAINE HYDROCHLORIDEPRILOCAINE HYDROCHLORIDELIDOCAINE HYDROCHLORIDEDICHLOROBENZYL ALCOHOLPHENAZOPYRIDINE HYDROCHLORIDEPRIMIDONEANTICONVULSANT AGENTPHENACEMIDEMEXILETINE HYDROCHLORIDEROPIVACAINE HYDROCHLORIDELACOSAMIDEPHENOBARBITALENCAINIDE HYDROCHLORIDENKTR-171MORICIZINE HYDROCHLORIDECARBAMAZEPINEOXCARBAZEPINEARTICAINE HYDROCHLORIDEQUINIDINE POLYGALACTURONATEELPETRIGINEBENOXINATE HYDROCHLORIDEHEXYLCAINE HYDROCHLORIDEORPHENADRINE HYDROCHLORIDETETRODOTOXIN
Antibody
Interaction Protein
ENSG00000196361
Interaction Count
1
Interaction Dataset
intact_biogrid