Protein detail
DCE1
Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform)
Protein symbol DCE1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- ENZYME proteins:Lyases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
GAD
Gene Description
Glutamate decarboxylase 1
Chromosome
2
Position
170813213-170861151
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificHofbauer cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- ENZYME proteins:Lyases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0005938 cell cortex
- GO:0012506 vesicle membrane
- GO:0043679 axon terminus
- GO:0048471 perinuclear region of cytoplasm
- GO:0048786 presynaptic active zone
- GO:0060077 inhibitory synapse
- GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
- GO:0098982 GABA-ergic synapse
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GAD1 | PRKCE | Q02156 | T | 91 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | KEA:15147202ProtMapper:15147202HPRD:15147202SIGNOR:15147202 |
| GAD1 | PPP1CA | P62136 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202 |
| GAD1 | PPP1CB | P62140 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202 |
| GAD1 | PPP1CC | P36873 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202 |
| GAD1 | PPP2CA | P67775 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202 |
| GAD1 | PPP2CB | P62714 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202 |
| GAD1 | PPP3CA | Q08209 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202DEPOD:7896780 |
| GAD1 | PPP3CB | P16298 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202DEPOD:7896780 |
| GAD1 | PPP3CC | P48454 | T | 91 | dephosphorylation | DEPOD | DEPOD:15147202DEPOD:7896780 |
| GAD1 | PRKACA | P17612 | T | 91 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | HPMR | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCE | Q02156 | DCE1 | Q99259 | Yes | No | Yes | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | HPRD:15147202SIGNOR:15147202HPRD-phos:15147202ProtMapper:15147202KEA:15147202 |
| KAPCA | P17612 | DCE1 | Q99259 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:15147202 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GABA_byGAD1_and_SLC32A1 | GAD1SLC32A1 | Q99259Q9H598 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:GABA_byGAD1_and_SLC32A1 | |
| GABA_byGAD1_and_SLC6A1 | GAD1SLC6A1 | P30531Q99259 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:GABA_byGAD1_and_SLC6A1 | |
| GABA_byGAD1_and_SLC6A12 | GAD1SLC6A12 | P48065Q99259 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:GABA_byGAD1_and_SLC6A12 | |
| GABA_byGAD1_and_SLC6A13 | GAD1SLC6A13 | Q99259Q9NSD5 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:GABA_byGAD1_and_SLC6A13 | |
| Glutamate decarboxylase 1 complex | GAD1 | Q99259 | 2 | ComplexPortalPDB | PDB:2okjintact:EBI-9293677PDB:3vp6 | 173846441475529220636380 |
| Glutamate decarboxylase 1/2 complex | GAD1GAD2 | Q05329Q99259 | 1:1 | ComplexPortal | intact:EBI-9491125 | 1475529220636380 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
594
Mass
66,897
Sequence
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=GAD67; IsoId=Q99259-1; Sequence=Displayed; Name=2; IsoId=Q99259-2; Sequence=Not described; Name=3; Synonyms=GAD25; IsoId=Q99259-3; Sequence=VSP_009123, VSP_009124; Name=4; IsoId=Q99259-4; Sequence=VSP_054473, VSP_054474
Alternative Sequence
214..224; FTYEIAPVFVL -> PSDMRECWLLR (in isoform 3); 225..594; Missing (in isoform 3); 374..425; AAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQ -> GFNFSQLANRIICLATELMTNKGCVTWHPNYSVNMHHGCLGRWAAHVQEAPP (in isoform 4); 426..594; Missing (in isoform 4)
3D Structural Models
Turn
94..97; 216..218; 384..386; 433..435
Helix
100..102; 110..131; 144..149; 165..177; 197..209; 220..237; 252..267; 270..274; 276..278; 293..300; 305..307; 321..333; 356..366; 377..382; 387..390; 393..395; 423..428; 444..446; 449..451; 461..495; 520..522; 529..549; 577..591
Beta Strand
187..192; 212..214; 241..243; 245..251; 282..287; 308..311; 337..346; 348..350; 369..374; 397..401; 414..420; 500..506; 509..511; 513..517; 553..559; 562..568
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1..13; Low complexity
Region
1..23; Disordered
Protein Families
Group II decarboxylase family
Sequence Similarities
Belongs to the group II decarboxylase family.
Clinical Relevance
Disease Involvement
Disease variantEpilepsyIntellectual disability
Related Diseases
Biomarker
Phase 2
Interaction Protein
ENSG00000147676
Interaction Count
1
Interaction Dataset
intact_biogrid