Protein detail

STAC

SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein)

Entry name STAC	UniProt ID Q99469	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein)

Protein Class

Predicted intracellular proteinsTransporters

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Ensembl

ENSG00000144681

Entrez Gene Symbol

STAC

Gene Synonym

STAC1

Gene Description

SH3 and cysteine rich domain

Chromosome

Position

36380503-36548007

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificparathyroid glandCell SpecificEpicardial cellsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CACNA1S STAC2	Q13698 Q6ZMT1	6:6	PDB	PDB:6b27
RP1L1 STAC3	Q8IWN7 Q96MF2	0:0	hu.MAP2
STAC3	Q96MF2	4	PDB	PDB:6uy8PDB:6b29

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMORPHELISA	4	39949490 26801919 40098346 40311616

Sequence, Structure & Domains

Sequences

Length

402

Mass

44,554

Sequence

MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI

3D Structural Models

Helix

336..338; 359..361; 396..398

Beta Strand

289..294; 311..316; 319..327; 330..335; 339..341; 347..353; 371..374; 382..387; 390..395

3D Structure

NMR spectroscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Zinc Finger

107..159; Phorbol-ester/DAG-type

Domain (FT)

285..344; SH3 1; 347..402; SH3 2

Region

1..47; Disordered; 211..247; Disordered

Clinical Relevance

Antibody

HPA035143

Interaction Protein

ENSG00000108953

Interaction Count

Interaction Dataset

intact_biogrid