Protein detail
S1PR3
Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3)
Entry name S1PR3 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3)
Protein Function (3)
- G-protein coupled receptors:Lysolipids receptors
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
41..65; Helical; Name=1; 73..101; Helical; Name=2; 116..134; Helical; Name=3; 154..179; Helical; Name=4; 196..216; Helical; Name=5; 244..265; Helical; Name=6; 282..302; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization4
Tissue Specificfallopian tubeCell SpecificCardiomyocytesSingle-Nuclei Brain Specificependymal cellBlood Cell Specificplasmacytoid DC
Function & Pathway7
Protein Function (3)
- G-protein coupled receptors:Lysolipids receptors
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
KEGG (2)
Reactome (8)
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-8939211 esr mediated signaling
- R-hsa-9009391 extra nuclear estrogen signaling
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-419408 lysosphingolipid and lpa receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-9006931 signaling by nuclear receptors
Mediation Categories (3)
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence65
Ligand-Receptor Signaling (50)
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Regulatory Interaction Network (12)
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| S1PR3 | Q99500 | GNA14 | O95837 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| S1PR3 | Q99500 | GNAI1 | P63096 | Yes | Yes | No | WangHPRDHINTSIGNOR | SIGNOR:31160049HPRD:10488065HINT:34545189SIGNOR:10488065 |
| S1PR3 | Q99500 | GNAQ | P50148 | Yes | Yes | No | HPRDSIGNOR | HPRD:10488065SIGNOR:31160049 |
| S1PR3 | Q99500 | GNAI3 | P08754 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR3 | Q99500 | GNA13 | Q14344 | Yes | Yes | No | HPRDSIGNOR | HPRD:10488065SIGNOR:10488065 |
| S1PR3 | Q99500 | GNAL | P38405 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| S1PR3 | Q99500 | GNAZ | P19086 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR3 | Q99500 | GNAO | P09471 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR3 | Q99500 | ALEX | P84996 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| S1PR3 | Q99500 | GNAS3 | O95467 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
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Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 34265469 |
Sequence, Structure & Domains11
Sequences
Length
378
Mass
42,250
Sequence
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
3D Structural Models
Turn
103..105; 149..151; 271..273; 291..293
Helix
17..25; 41..66; 74..99; 108..139; 152..169; 172..174; 194..228; 232..268; 275..280; 281..290; 294..298; 303..311
Beta Strand
26..28; 179..181; 182..185; 187..189; 300..302
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
337..348; Low complexity
Region
327..357; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance3
Related Diseases
Biomarker
Preclinical