Protein detail

SORT

Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)

Protein symbol SORT	UniProt ID Q99523	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)

Protein Class

Disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Disease related genes
Transporters
Predicted intracellular proteins
Potential drug targets

Transmembrane

756..778; Helical

Transmembrane Count

Ensembl

ENSG00000134243

Entrez Gene Symbol

SORT1

Gene Synonym

Gp95NT3

Gene Description

Sortilin 1

Chromosome

Position

109309568-109397918

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificliverCell SpecificHepatocytesSingle-Nuclei Brain Specifichippocampal CA1-3Blood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Disease related genes
Transporters
Predicted intracellular proteins
Potential drug targets

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SORT1	CSNK2B	P67870	S	825	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
SORT1	PAK2	Q13177	S	793	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PAK1	Q13153	SORT	Q99523	Yes	No	Yes	SIGNOR	SIGNOR:31767632
	COMPLEX:O43747_P61966_Q10567_Q9BXS5	SORT	Q99523	Yes	Yes	No	SIGNOR	SIGNOR:31767632
PAK3	O75914	SORT	Q99523	Yes	No	Yes	SIGNOR	SIGNOR:31767632
PAK2	Q13177	SORT	Q99523	Yes	No	Yes	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	SIGNOR:31767632 PhosphoSite:25805502 PhosphoSite:31767632
SORT	Q99523	APOA1	P02647	Yes	Yes	No	SIGNOR	SIGNOR:23283348
SORT	Q99523	APOE	P02649	Yes	Yes	No	SIGNOR	SIGNOR:23283348
CSK2B	P67870	SORT	Q99523	Yes	Yes	No	iPTMnetPhosphoSite_norefSIGNORProtMapperPhosphoSite_ProtMapper	SIGNOR:25805502

Protein Complex Composition

22 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
SNX1 SORT1 TBC1D5 TYW1B UBC VPS26A VPS26B VPS29 VPS35	O75436 P0CG48 Q13596 Q4G0F5 Q6NUM6 Q92609 Q96QK1 Q99523 Q9UBQ0	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5405
SLC66A2 SNX1 SORT1 UBC VPS26A VPS26B VPS29 VPS35	O75436 P0CG48 Q13596 Q4G0F5 Q8N2U9 Q96QK1 Q99523 Q9UBQ0	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9018
REEP6 SNX1 SORT1 UBC VPS26A VPS26B VPS29 VPS35	O75436 P0CG48 Q13596 Q4G0F5 Q96HR9 Q96QK1 Q99523 Q9UBQ0	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9116
EDEM2 SNX1 SORT1 UBC VPS26A VPS26B VPS29 VPS35	O75436 P0CG48 Q13596 Q4G0F5 Q96QK1 Q99523 Q9BV94 Q9UBQ0	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7038
MTMR4 SNX1 SORT1 UBC VPS26A VPS26B VPS29 VPS35	O75436 P0CG48 Q13596 Q4G0F5 Q96QK1 Q99523 Q9NYA4 Q9UBQ0	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6212
MTMR8 MTMR9 SETD3 SNX1 SORT1 UBC VPS26A VPS29 VPS35	O75436 P0CG48 Q13596 Q86TU7 Q96EF0 Q96QG7 Q96QK1 Q99523 Q9UBQ0	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9216
MTMR6 MTMR9 SETD3 SNX1 SORT1 UBC VPS26A VPS29 VPS35	O75436 P0CG48 Q13596 Q86TU7 Q96QG7 Q96QK1 Q99523 Q9UBQ0 Q9Y217	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5881
MTMR6 MTMR8 MTMR9 SNX1 SORT1 UBC VPS26A VPS29 VPS35	O75436 P0CG48 Q13596 Q96EF0 Q96QG7 Q96QK1 Q99523 Q9UBQ0 Q9Y217	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8581
GRN SORT1	P28799 Q99523	2:2	PDB	PDB:8t8rPDB:8t8s
NTS SORT1	P30990 Q99523	2:1	PDB	PDB:4po7PDB:3f6k

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	37714423

Sequence, Structure & Domains

Sequences

Length

831

Mass

92,068

Sequence

MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAPGEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTNKSGYHDDSDEDLLE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99523-1; Sequence=Displayed; Name=2; IsoId=Q99523-2; Sequence=VSP_046239, VSP_046240

Alternative Sequence

1..136; Missing (in isoform 2); 278..279; KA -> T (in isoform 2)

3D Structural Models

Turn

177..179; 277..282; 333..335; 397..399; 449..451; 576..578; 630..633

Helix

92..97; 135..137; 158..161; 168..170; 263..265; 465..469; 529..531; 591..593; 604..606; 614..616; 670..672; 696..704; 707..710; 737..740; 741..743

Beta Strand

100..106; 110..116; 118..121; 124..130; 141..149; 152..154; 163..167; 172..174; 182..186; 187..190; 196..202; 208..211; 216..218; 221..223; 226..234; 239..244; 247..261; 267..271; 273..275; 283..291; 297..309; 312..318; 320..323; 325..332; 351..356; 361..366; 368..370; 372..379; 381..383; 385..395; 405..410; 414..419; 421..423; 425..432; 438..441; 446..448; 453..456; 459..462; 482..484; 488..497; 504..510; 516..521; 523..528; 533..538; 540..542; 546..552; 558..561; 567..573; 581..590; 595..603; 617..621; 638..645; 661..665; 673..675; 683..685; 714..717; 724..726; 734..736

3D Structure

X-ray crystallography (14)

Domain & Motif Annotations

Repeat

145..156; BNR 1; 198..209; BNR 2; 240..251; BNR 3; 287..298; BNR 4; 328..339; BNR 5; 377..388; BNR 6; 428..439; BNR 7; 506..517; BNR 8; 548..559; BNR 9

Motif

787..792; Endocytosis signal; 826..830; DXXLL motif involved in the interaction with GGA1

Domain (CC)

The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N-terminal propeptide and the extracellular domain may also inhibit premature ligand binding.; DOMAIN: The extracellular domain may be shed following protease cleavage in some cell types.

Domain (FT)

98..742; Vps10p

Region

50..61; Intrachain binding of the propeptide and the extracellular domain; 98..604; 10-bladed beta-propeller; 612..756; Interactions with LRPAP1 and NGFB; 612..666; 10CCa cysteine-knot; 668..742; 10CCb cysteine-knot; 779..831; Golgi to endosome transport and interactions with GGA1 and GGA2

Protein Families

VPS10-related sortilin family
SORT1 subfamily

Sequence Similarities

Belongs to the VPS10-related sortilin family. SORT1 subfamily.

Clinical Relevance

Related Diseases

Frontotemporal dementia Motor neuron disease Neurodegenerative disorder

Biomarker

Phase 3; Phase 2; Phase 1

Drugs

NULL

Antibody

HPA006889 CAB011498

Interaction Protein

ENSG00000100083ENSG00000103365ENSG00000123374ENSG00000134259ENSG00000140538ENSG00000163956ENSG00000198400

Interaction Count

Interaction Dataset

intact_biogrid