Protein detail

PKP4

Plakophilin-4 (p0071)

Entry name PKP4	UniProt ID Q99569	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Plakophilin-4 (p0071)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000144283

Entrez Gene Symbol

PKP4

Gene Synonym

p0071

Gene Description

Plakophilin 4

Chromosome

Position

158456952-158682879

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization8

Tissue SpecificovaryCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cellsSecretome LocationSecreted to extracellular matrixSecretome FunctionEnzyme

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (17)

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Molecular Function (2)

Biological Process (3)

Reactome (7)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence22

Enzyme-Mediated Modification (7)

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PKP4	ABL1	P00519	Y	478	phosphorylation	KEA	KEA:17570479
PKP4	CDK2	P24941	S	1,049	phosphorylation	KEA	KEA:17570479
PKP4	CDK2	P24941	S	336	phosphorylation	KEA	KEA:17570479
PKP4	MAPK14	Q16539	S	1,049	phosphorylation	KEA	KEA:17570479
PKP4	MAPK14	Q16539	S	336	phosphorylation	KEA	KEA:17570479
PKP4	PRKCB	P05771	S	336	phosphorylation	KEA	KEA:17570479
PKP4	RPS6KA3	P51812	S	512	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
matrix_adhesion	matrix_adhesion	Zhong2015	No	Yes	No	No	No
focal_adhesion	matrix_adhesion	Zhong2015	No	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
matrix_adhesion	matrix_adhesion	OmniPath	No	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CTAG2 OSGEP PGAM1 PKP4 TP53RK TPRKB UBC	O75638 P0CG48 P18669 Q96S44 Q99569 Q9NPF4 Q9Y3C4	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6457
DNAJA1 LAGE3 OSGEP PKP4 TP53RK TPRKB UBC	P0CG48 P31689 Q14657 Q96S44 Q99569 Q9NPF4 Q9Y3C4	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8047
CLEC11A PKP4	Q99569 Q9Y240	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	12	38113368 37322475 33936570 40189497 33592500 32854315 36146834 33309826 37670049 38607062 38207106 34576246

Sequence, Structure & Domains11

Sequences

Length

1,192

Mass

131,868

Sequence

MPAPEQASLVEEGQPQTRQEAASTGPGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLPAARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q99569-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q99569-2; Sequence=VSP_006737

Alternative Sequence

1043..1085; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

77..86; Polar residues; 138..156; Polar residues; 163..204; Polar residues; 214..230; Polar residues; 231..242; Low complexity; 325..338; Low complexity; 773..782; Basic and acidic residues; 1067..1077; Polar residues

Repeat

415..455; ARM 1; 518..557; ARM 2; 560..599; ARM 3; 604..644; ARM 4; 660..702; ARM 5; 706..751; ARM 6; 815..855; ARM 7; 862..901; ARM 8; 950..993; ARM 9

Coiled Coil

36..70

Region

1..31; Disordered; 73..262; Disordered; 290..310; Disordered; 323..348; Disordered; 773..810; Disordered; 1058..1086; Disordered

Protein Families

Beta-catenin family

Sequence Similarities

Belongs to the beta-catenin family.

Clinical Relevance4

Antibody (3)

CAB037334 HPA066647 HPA070648

Interaction Protein (2)

ENSG00000080815ENSG00000112851

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available