Protein detail
PKP4
Plakophilin-4 (p0071)
Protein symbol PKP4 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Plakophilin-4 (p0071)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
p0071
Gene Description
Plakophilin 4
Chromosome
2
Position
158456952-158682879
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificovaryCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cellsSecretome LocationSecreted to extracellular matrixSecretome FunctionEnzyme
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0000922 spindle pole
- GO:0001533 cornified envelope
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0014069 postsynaptic density
- GO:0030054 cell junction
- GO:0030057 desmosome
- GO:0030496 midbody
- GO:0044291 cell-cell contact zone
- GO:0048471 perinuclear region of cytoplasm
- GO:0051233 spindle midzone
- GO:0072686 mitotic spindle
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PKP4 | ABL1 | P00519 | Y | 478 | phosphorylation | KEA | KEA:17570479 |
| PKP4 | CDK2 | P24941 | S | 1,049 | phosphorylation | KEA | KEA:17570479 |
| PKP4 | CDK2 | P24941 | S | 336 | phosphorylation | KEA | KEA:17570479 |
| PKP4 | MAPK14 | Q16539 | S | 1,049 | phosphorylation | KEA | KEA:17570479 |
| PKP4 | MAPK14 | Q16539 | S | 336 | phosphorylation | KEA | KEA:17570479 |
| PKP4 | PRKCB | P05771 | S | 336 | phosphorylation | KEA | KEA:17570479 |
| PKP4 | RPS6KA3 | P51812 | S | 512 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | No | No |
| focal_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CTAG2OSGEPPGAM1PKP4TP53RKTPRKBUBC | O75638P0CG48P18669Q96S44Q99569Q9NPF4Q9Y3C4 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6457 | ||
| DNAJA1LAGE3OSGEPPKP4TP53RKTPRKBUBC | P0CG48P31689Q14657Q96S44Q99569Q9NPF4Q9Y3C4 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8047 | ||
| CLEC11APKP4 | Q99569Q9Y240 | 0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 12 | 381133683732247533936570401894973359250032854315361468343330982637670049386070623820710634576246 |
Sequence, Structure & Domains
Sequences
Length
1,192
Mass
131,868
Sequence
MPAPEQASLVEEGQPQTRQEAASTGPGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLPAARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q99569-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q99569-2; Sequence=VSP_006737
Alternative Sequence
1043..1085; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
77..86; Polar residues; 138..156; Polar residues; 163..204; Polar residues; 214..230; Polar residues; 231..242; Low complexity; 325..338; Low complexity; 773..782; Basic and acidic residues; 1067..1077; Polar residues
Repeat
415..455; ARM 1; 518..557; ARM 2; 560..599; ARM 3; 604..644; ARM 4; 660..702; ARM 5; 706..751; ARM 6; 815..855; ARM 7; 862..901; ARM 8; 950..993; ARM 9
Coiled Coil
36..70
Region
1..31; Disordered; 73..262; Disordered; 290..310; Disordered; 323..348; Disordered; 773..810; Disordered; 1058..1086; Disordered
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.