Protein detail

P2RX7

P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)

Entry name P2RX7	UniProt ID Q99572	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 2	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

23..46; Helical; Name=1; 329..353; Helical; Name=2

Transmembrane Count

Ensembl

ENSG00000089041

Entrez Gene Symbol

P2RX7

Gene Synonym (2)

MGC20089P2X7

Gene Description

Purinergic receptor P2X 7

Chromosome

Position

121132819-121188032

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway7

Protein Function

Transporters:Transporter channels and pores

Cellular Component (11)

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Molecular Function (7)

Biological Process (3)

KEGG (3)

Reactome (14)

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Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence44

Ligand-Receptor Signaling (43)

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ion_channel	ion_channel	DGIdb	No	Yes	No	Yes	No
ion_channel	ion_channel	Almen2009	No	Yes	No	Yes	No
atp_gated	ion_channel	Almen2009	No	Yes	No	Yes	No
ligand_gated	ion_channel	Almen2009	No	Yes	No	Yes	No
atp_gated	ion_channel	Surfaceome	No	Yes	No	Yes	No
ligand_gated	ion_channel	Surfaceome	No	Yes	No	Yes	No
transporter	transporter	OmniPath	No	Yes	No	Yes	No
ion_channel	ion_channel	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40689422

Sequence, Structure & Domains9

Sequences

Length

595

Mass

68,585

Sequence

MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY

Alternative Products

Event=Alternative splicing; Named isoforms=9; Name=A; IsoId=Q99572-1; Sequence=Displayed; Name=B; Synonyms=Delta-C, cytoplasmic tail deleted; IsoId=Q99572-2; Sequence=VSP_047784, VSP_047785; Name=C; IsoId=Q99572-3; Sequence=VSP_047781, VSP_047782; Name=D; IsoId=Q99572-4; Sequence=VSP_047777, VSP_047780; Name=E; IsoId=Q99572-5; Sequence=VSP_047783, VSP_047784, VSP_047785; Name=F; IsoId=Q99572-6; Sequence=VSP_047778, VSP_047779; Name=G; IsoId=Q99572-7; Sequence=VSP_047776, VSP_047784, VSP_047785; Name=H; Synonyms=Delta-TM1; IsoId=Q99572-8; Sequence=VSP_047776; Name=J; Synonyms=Isoform P; IsoId=Q99572-9; Sequence=VSP_062514, VSP_062515

Alternative Sequence

1..98; MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQ -> MTPGDHSW (in isoform G and isoform H); 1..7; MPACCSC -> MDGPAEQ (in isoform D); 1..3; MPA -> MWQ (in isoform F); 4..292; Missing (in isoform F); 8..177; Missing (in isoform D); 122..128; YPTRRTL -> EFRPEGV (in isoform C); 129..595; Missing (in isoform C); 206..294; Missing (in isoform E); 249..258; GGIMGIEIYW -> IRQVLQGKQC (in isoform J); 259..595; Missing (in isoform J); 347..364; AAVFIDFLIDTYSSNCCR -> VRDSLFHALGKWFGEGSD (in isoform B, isoform E and isoform G); 365..595; Missing (in isoform B, isoform E and isoform G)

Domain & Motif Annotations

Domain (CC)

Contains two P2RX7-specific cytoplasmic domains, the C-cysteines (C-cys) anchor and the cytoplasmic ballast. Palmitoylation of the cytoplasmic C-cys anchor prevents receptor desensitization. The cytoplasmic ballast contains a zinc ion complex and a guanosine nucleotide binding site.; DOMAIN: The ion selectivity is determined by two sequential filters: a dynamic tri-Ser-342 size filter and three conformationally static cation filters.

Region

360..377; C-cys anchor; 395..595; Cytoplasmic ballast

Protein Families

P2X receptor family

Sequence Similarities

Belongs to the P2X receptor family.

Clinical Relevance4

Related Diseases (13)

Alzheimer disease Chronic obstructive pulmonary disease CNS non-viral infection Depression Diabetes mellitus Indeterminate colitis Joint pain Mood disorder Mood/affect symptom Pain Postoperative inflammation Rheumatoid arthritis Solid tumour/cancer

Biomarker

Phase 1/2; Phase 2; Phase 1; Investigative; Phase 2/3

Drugs (6)

GSK1482160 CE-224535 AZD9056 EVT401 JNJ-54175446 JNJ-47965567

Antibody (3)

HPA034968 HPA042013 HPA044141

Supporting Publications1

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.