Protein detail
I12R2
Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
Protein symbol I12R2 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 1 | Protein classification Human disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
Protein Class
Human disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Transmembrane
623..643; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Interleukin 12 receptor subunit beta 2
Chromosome
1
Position
67307364-67398724
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificNeutrophilsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IL12RB2 | NOS2 | P35228 | Y | 800 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:8943050ProtMapper:10320373 |
| IL12RB2 | IL1B | P01584 | Y | 800 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:9454765ProtMapper:7594594ProtMapper:9038232ProtMapper:8943050ProtMapper:7528775ProtMapper:10198225 |
Ligand-Receptor Signaling
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IL12A | P29459 | I12R2 | Q99665 | Yes | Yes | No | Guide2PharmaHPMRCellTalkDBiTALKtalklrUniProt_LRdbRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019DLRP_talklrDIPWangLRdbSTRING_talklrCellCall | LRdb:943050SIGNOR:11086056DIP:8943050HPMR:11086056Ramilowski2015:943050connectomeDB2020:943050talklr:943050CellTalkDB:943050 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL12A-IL12B-IL12RB2 complex | IL12AIL12BIL12RB2 | P29459P29460Q99665 | 1:1:1 | CompleatCORUM | Compleat:HC3488CORUM:2021 | 9498755 |
| JAK2-IL12RB2 complex | IL12RB2JAK2 | O60674Q99665 | 1:1 | CompleatCORUM | Compleat:HC3313CORUM:2028 | 9038232 |
| IL12RB2IL27RA | Q6UWB1Q99665 | 0:0 | CellinkerICELLNET | 24743305 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingFlow cytometry | 1 | 38321535 |
Sequence, Structure & Domains
Sequences
Length
862
Mass
97,135
Sequence
MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99665-1; Sequence=Displayed; Name=2; IsoId=Q99665-2; Sequence=VSP_011112, VSP_011113; Name=3; IsoId=Q99665-3; Sequence=VSP_044784
Alternative Sequence
487..572; Missing (in isoform 3); 650..659; VFVLLAALRP -> RRHSCPWTGS (in isoform 2); 660..862; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
728..744; Basic and acidic residues
Motif
305..309; WSXWS motif; 662..670; Box 1 motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.
Domain (FT)
126..221; Fibronectin type-III 1; 226..319; Fibronectin type-III 2; 320..419; Fibronectin type-III 3; 423..520; Fibronectin type-III 4; 521..620; Fibronectin type-III 5
Region
725..755; Disordered; 796..801; Required for STAT4 binding
Protein Families
- Type I cytokine receptor family
- Type 2 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Clinical Relevance
Antibody