Protein detail
I12R2
Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
Entry name I12R2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification Human disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
Protein Class (3)
Human disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Transmembrane
623..643; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Interleukin 12 receptor subunit beta 2
Chromosome
1
Position
67307364-67398724
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificNeutrophilsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (3)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (5)
Reactome (6)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence60
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IL12RB2 | NOS2 | P35228 | Y | 800 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:8943050ProtMapper:10320373 |
| IL12RB2 | IL1B | P01584 | Y | 800 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:9454765ProtMapper:7594594ProtMapper:9038232ProtMapper:8943050ProtMapper:7528775ProtMapper:10198225 |
Ligand-Receptor Signaling (53)
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IL12A | P29459 | I12R2 | Q99665 | Yes | Yes | No | Guide2PharmaHPMRCellTalkDBiTALKtalklrUniProt_LRdbRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019DLRP_talklrDIPWangLRdbSTRING_talklrCellCall | LRdb:943050SIGNOR:11086056DIP:8943050HPMR:11086056Ramilowski2015:943050connectomeDB2020:943050talklr:943050CellTalkDB:943050 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL12A-IL12B-IL12RB2 complex | IL12AIL12BIL12RB2 | P29459P29460Q99665 | 1:1:1 | CompleatCORUM | Compleat:HC3488CORUM:2021 | 9498755 |
| JAK2-IL12RB2 complex | IL12RB2JAK2 | O60674Q99665 | 1:1 | CompleatCORUM | Compleat:HC3313CORUM:2028 | 9038232 |
| IL12RB2IL27RA | Q6UWB1Q99665 | 0:0 | CellinkerICELLNET | 24743305 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingFlow cytometry | 1 | 38321535 |
Sequence, Structure & Domains13
Sequences
Length
862
Mass
97,135
Sequence
MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99665-1; Sequence=Displayed; Name=2; IsoId=Q99665-2; Sequence=VSP_011112, VSP_011113; Name=3; IsoId=Q99665-3; Sequence=VSP_044784
Alternative Sequence
487..572; Missing (in isoform 3); 650..659; VFVLLAALRP -> RRHSCPWTGS (in isoform 2); 660..862; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
728..744; Basic and acidic residues
Motif
305..309; WSXWS motif; 662..670; Box 1 motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.
Domain (FT)
126..221; Fibronectin type-III 1; 226..319; Fibronectin type-III 2; 320..419; Fibronectin type-III 3; 423..520; Fibronectin type-III 4; 521..620; Fibronectin type-III 5
Region
725..755; Disordered; 796..801; Required for STAT4 binding
Protein Families (2)
- Type I cytokine receptor family
- Type 2 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Clinical Relevance2
Drugs (3)
Antibody
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 23161513 | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins. |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No abstract available |
| 36635400 | Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |