Protein detail
KCJ15
ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)
Protein symbol KCJ15 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count 2 | Protein classification FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteinsVoltage-gated ion channels |
Basic Information
Protein Names
ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)
Protein Class
FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteinsVoltage-gated ion channels
Protein Function
- Voltage-gated ion channels:Inwardly Rectifying Potassium Channels
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
61..87; Helical; Name=M1; 140..165; Helical; Name=M2
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym
IRKKKir1.3Kir4.2
Gene Description
Potassium inwardly rectifying channel subfamily J member 15
Chromosome
21
Position
38155549-38307357
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Voltage-gated ion channels:Inwardly Rectifying Potassium Channels
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component
Biological Process
Reactome
- R-hsa-977444 gaba b receptor activation
- R-hsa-977443 gaba receptor activation
- R-hsa-1296065 inwardly rectifying k channels
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-1296071 potassium channels
- R-hsa-112315 transmission across chemical synapses
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingFlow cytometry | 1 | 38321535 |
Sequence, Structure & Domains
Sequences
Length
375
Mass
42,577
Sequence
MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQRERELRTLLLQQSNV
3D Structural Models
Domain & Motif Annotations
Motif
127..132; Selectivity filter
Protein Families
- Inward rectifier-type potassium channel (TC 1.A.2.1) family
- KCNJ15 subfamily
Sequence Similarities
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.