Protein detail
LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Protein symbol LITAF | UniProt ID | EVMP score 0.50 |
Frequency 6 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ38636PIG7SIMPLETP53I7
Gene Description
Lipopolysaccharide induced TNF factor
Chromosome
16
Position
11547722-11636381
Frequency
6
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005765 lysosomal membrane
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0098559 cytoplasmic side of early endosome membrane
- GO:0098560 cytoplasmic side of late endosome membrane
- GO:0098574 cytoplasmic side of lysosomal membrane
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
161
Mass
17,107
Sequence
MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99732-1; Sequence=Displayed; Name=2; IsoId=Q99732-2; Sequence=VSP_016461; Name=3; IsoId=Q99732-3; Sequence=VSP_045701
Alternative Sequence
127..161; CIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL -> VHSGLLLHPLLRGCPAGRGPLLSQLQSSPGHLQAFVGLSQTWREPGAAGSPFHLSSSFTPGGGSALVVSPLQGAHLHVFFWGEYVAKLTNLQTPEIAAWSRA (in isoform 2); 127..161; CIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL -> QECSGTIVALRSFDLLGSCNPPSSAS (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Motif
17..20; PSAP motif; important for interaction with TSG101; 20..23; PPxY motif
Domain (CC)
The PPxY motif mediates interaction with WWOX and NEDD4..; DOMAIN: The LITAF domain is stabilized by a bound zinc ion (PubMed:27582497, PubMed:27927196). The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes (PubMed:23166352, PubMed:27582497, PubMed:27927196). It interacts specifically with phosphatidylethanolamine lipid headgroups, but not with phosphoglycerol, phosphocholine, phosphoserine or inositolhexakisphosphate (PubMed:27927196).
Domain (FT)
76..160; LITAF
Region
1..22; Disordered; 111..134; Membrane-binding amphipathic helix
Protein Families
CDIP1/LITAF family
Sequence Similarities
Belongs to the CDIP1/LITAF family.
Clinical Relevance
Disease Involvement
Charcot-Marie-Tooth diseaseDisease variantNeurodegenerationNeuropathy
Antibody
Interaction Protein
ENSG00000069869ENSG00000074319ENSG00000116983ENSG00000151929ENSG00000153179
Interaction Count
5
Interaction Dataset
intact_biogrid