Protein detail
LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Entry name LITAF | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Protein Class (4)
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
FLJ38636PIG7SIMPLETP53I7
Gene Description
Lipopolysaccharide induced TNF factor
Chromosome
16
Position
11547722-11636381
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component (11)
- GO:0000139 Golgi membrane
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005765 lysosomal membrane
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0098559 cytoplasmic side of early endosome membrane
- GO:0098560 cytoplasmic side of late endosome membrane
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Molecular Function (6)
Biological Process (3)
Mediation Categories (3)
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence13
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (2)
Sequence, Structure & Domains
Sequences
Length
161
Mass
17,107
Sequence
MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99732-1; Sequence=Displayed; Name=2; IsoId=Q99732-2; Sequence=VSP_016461; Name=3; IsoId=Q99732-3; Sequence=VSP_045701
Alternative Sequence
127..161; CIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL -> VHSGLLLHPLLRGCPAGRGPLLSQLQSSPGHLQAFVGLSQTWREPGAAGSPFHLSSSFTPGGGSALVVSPLQGAHLHVFFWGEYVAKLTNLQTPEIAAWSRA (in isoform 2); 127..161; CIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL -> QECSGTIVALRSFDLLGSCNPPSSAS (in isoform 3)
Domain & Motif Annotations
Motif
17..20; PSAP motif; important for interaction with TSG101; 20..23; PPxY motif
Domain (CC)
The PPxY motif mediates interaction with WWOX and NEDD4..; DOMAIN: The LITAF domain is stabilized by a bound zinc ion (PubMed:27582497, PubMed:27927196). The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes (PubMed:23166352, PubMed:27582497, PubMed:27927196). It interacts specifically with phosphatidylethanolamine lipid headgroups, but not with phosphoglycerol, phosphocholine, phosphoserine or inositolhexakisphosphate (PubMed:27927196).
Domain (FT)
76..160; LITAF
Region
1..22; Disordered; 111..134; Membrane-binding amphipathic helix
Protein Families
CDIP1/LITAF family
Sequence Similarities
Belongs to the CDIP1/LITAF family.
Clinical Relevance
Disease Involvement (4)
Charcot-Marie-Tooth diseaseDisease variantNeurodegenerationNeuropathy
Related Diseases
Antibody
Interaction Protein (5)
ENSG00000069869ENSG00000074319ENSG00000116983ENSG00000151929ENSG00000153179
Interaction Count
5
Interaction Dataset
intact_biogrid
Supporting Publications6
| PMID | Title | Related sentences |
|---|---|---|
| 29436780 | Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells. | No related sentences available |
| 32284825 | Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. | No related sentences available |
| 33204424 | Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid. | No related sentences available |
| 35611462 | Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |