Protein detail

PI51A

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)

Entry name
PI51A
UniProt ID
Q99755
EVMP confidence score
0.50
Supporting publications (n)
1
Transmembrane count
Protein classification
Cancer-related genesEnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information10
Protein Names
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)
Protein Class (5)
Cancer-related genesEnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins
Protein Function (4)
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutational cancer driver genes
  • Enzymes
  • Predicted intracellular proteins
Ensembl
ENSG00000143398
Entrez Gene Symbol
PIP5K1A
Gene Description
Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Chromosome
1
Position
151197949-151249536
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway7
Protein Function (4)
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutational cancer driver genes
  • Enzymes
  • Predicted intracellular proteins
Cellular Component (9)
Molecular Function (7)
Biological Process (3)
KEGG (10)
Reactome (6)
Mediation Categories (4)
Adhesion and uptake mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence21

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PIP5K1ACASP3P42574D279cleavageHPRDHPRD:11042212

Ligand-Receptor Signaling (9)

9 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
receptorreceptorscConnectNoYesNoNoNo

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
DVL3Q92997PI51AQ99755YesYesNoSIGNORSignaLink3SignaLink3:18772438SignaLink3:23331499SIGNOR:18772438

Protein Complex Composition (9)

9 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
mRNA cleavage and polyadenylation specificity factor complexCPSF1CPSF2CPSF3CPSF4CSNK1A1CSTF2FIP1L1PIP5K1ATUT1O95639P33240P48729Q10570Q6UN15Q99755Q9H6E5Q9P2I0Q9UKF61:1:1:1:1:1:1:1:1CompleatCompleat:HC243818305108
NRXN3PIP5K1APIP5K1CRABGGTBO60331P53611Q99755Q9HDB50:0:0:0hu.MAP
NRXN3PIP5K1APIP5K1CRABGGTBO60331P53611Q99755Q9Y4C00:0:0:0hu.MAP
NRXN3PIP5K1APIP5K1CTRIM41O60331Q8WV44Q99755Q9HDB50:0:0:0hu.MAP
NRXN3PIP5K1APIP5K1CTRIM41O60331Q8WV44Q99755Q9Y4C00:0:0:0hu.MAP
PIP5K1APIP5K1CO60331Q997550:0hu.MAP2
NRXN3PIP5K1APIP5K1CO60331Q99755Q9HDB50:0:0hu.MAP2
NRXN3PIP5K1APIP5K1CO60331Q99755Q9Y4C00:0:0hu.MAP2
CSNK1A1PIP5K1AP48729Q997550:0Havugimana2012Havugimana2012:C_80

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing23426546936573687
Sequence, Structure & Domains7

Sequences

Length
562
Mass
62,633
Sequence
MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PIP5KIalpha2; IsoId=Q99755-1; Sequence=Displayed; Name=2; Synonyms=PIP5KIalpha3; IsoId=Q99755-2; Sequence=VSP_016007, VSP_016008; Name=3; Synonyms=PIP5KIalpha1; IsoId=Q99755-3; Sequence=VSP_016007; Name=4; IsoId=Q99755-4; Sequence=VSP_041912, VSP_041913
Alternative Sequence
30..52; ASGIKRPMASEVLEARQDSYISL -> SGIKRPMASE (in isoform 2 and isoform 3); 41..52; Missing (in isoform 4); 382..410; HMGGIPARNSKGERLLLYIGIIDILQSYR -> Q (in isoform 4); 455..504; LKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG -> C (in isoform 2)

Domain & Motif Annotations

Domain (FT)
81..449; PIPK
Region
506..526; Disordered
Clinical Relevance5
Disease Involvement
Cancer-related genes
Antibody
HPA029366
Interaction Protein
ENSG00000133703
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
PMIDTitleAbstract
40089067Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells.No abstract available