Protein detail
COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial (EC 1.14.13.253) (3-demethoxyubiquinone 3-hydroxylase (NADH)) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)
Protein symbol COQ7 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial (EC 1.14.13.253) (3-demethoxyubiquinone 3-hydroxylase (NADH)) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
CAT5CLK-1
Gene Description
Coenzyme Q7, hydroxylase
Chromosome
16
Position
19067614-19080095
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
- GO:0003682 chromatin binding
- GO:0005515 protein binding
- GO:0008682 3-demethoxyubiquinol 3-hydroxylase activity
- GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
- GO:0046872 metal ion binding
Biological Process
KEGG
Reactome
Mediation Categories
Immune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
217
Mass
24,277
Sequence
MSCAGAAAAPRLWRLRPGARRSLSAYGRRTSVRFRSSGMTLDNISRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKDHLKKFNELMVTFRVRPTVLMPLWNVLGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQLIKKFRDEELEHHDIGLDHDAELAPAYAVLKSIIQAGCRVAIYLSERL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99807-1; Sequence=Displayed; Name=2; IsoId=Q99807-2; Sequence=VSP_039068
Alternative Sequence
1..38; Missing (in isoform 2)
3D Structural Models
Turn
126..128; 157..159; 161..164; 182..185
Helix
46..74; 80..104; 112..125; 131..156; 165..177; 194..214
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Repeat
48..129; 1; 130..217; 2
Region
11..29; Required for nuclear localization; 48..217; 2 X approximate tandem repeats
Protein Families
COQ7 family
Sequence Similarities
Belongs to the COQ7 family.