Protein detail
S29A1
Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)
Entry name S29A1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 11 | Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)
Protein Class (4)
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
13..29; Helical; 83..107; Helical; 112..130; Helical; 139..157; Helical; 175..199; Helical; 207..227; Helical; 292..311; Helical; 324..342; Helical; 360..378; Helical; 394..413; Helical; 432..452; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
ENT1
Gene Description
Solute carrier family 29 member 1 (Augustine blood group)
Chromosome
6
Position
44219553-44234142
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificsalivary glandCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (9)
- GO:0005326 neurotransmitter transmembrane transporter activity
- GO:0005337 nucleoside transmembrane transporter activity
- GO:0015207 adenine transmembrane transporter activity
- GO:0015208 guanine transmembrane transporter activity
- GO:0015210 uracil transmembrane transporter activity
- GO:0015211 purine nucleoside transmembrane transporter activity
- GO:0015212 cytidine transmembrane transporter activity
- GO:0015213 uridine transmembrane transporter activity
- GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity
Biological Process (3)
Reactome (7)
- R-hsa-9748787 azathioprine adme
- R-hsa-9748784 drug adme
- R-hsa-9755088 ribavirin adme
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-83936 transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
- R-hsa-382551 transport of small molecules
- R-hsa-425397 transport of vitamins nucleosides and related molecules
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence39
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLC29A1 | PRKCD | Q05655 | S | 281 | phosphorylation | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | SIGNOR:25725289 |
| SLC29A1 | CSNK2A1 | P68400 | S | 254 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (33)
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| slc | transporter | Surfaceome | Yes | Yes | |||
| transporter | transporter | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | CellPhoneDB | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | LOCATE | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCD | Q05655 | S29A1 | Q99808 | Yes | Yes | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:25725289PhosphoSite:25725289ProtMapper:25725289 | |
| CSK21 | P68400 | S29A1 | Q99808 | Yes | Yes | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | SIGNOR:17520485PhosphoSite:26406980 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains
Sequences
Length
456
Mass
50,219
Sequence
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99808-1; Sequence=Displayed; Name=2; IsoId=Q99808-2; Sequence=VSP_056579
Alternative Sequence
1; M -> MRRERTRGPQAWEFPSPTKSGCSLQSLSRDLRELREGEKPEDQAETEESWQGLARKTPGKACAPEGGSCQPGKTENTITM (in isoform 2)
3D Structural Models
Turn
307..310; 348..350
Helix
10..12; 13..34; 36..44; 77..102; 103..105; 108..131; 136..165; 170..197; 201..224; 230..236; 237..239; 282..306; 311..313; 322..324; 325..332; 334..347; 360..367; 368..370; 371..376; 393..417; 418..421; 424..449
Beta Strand
380..382; 384..386
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
254..266; Basic and acidic residues
Domain (CC)
Cys-414 near TM10 is a major determinant of nucleobase transport activity.
Region
254..276; Disordered
Protein Families
SLC29A/ENT transporter (TC 2.A.57) family
Sequence Similarities
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Clinical Relevance
Related Diseases
Biomarker
Approved
Drugs (60)
LADUVIGLUSIBRIBAVIRINDEHYDRATED ALCOHOLGSK-3&BETAINHIBITOR 3 [PMID: 25845281]TIPIRACIL HYDROCHLORIDECOMPOUND 4G [PMID: 2680437]2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)ETHANOLSB-415286COMPOUND 5 [PMID: 19338355]TIDEGLUSIB7-HYDROXYSTAUROSPORINEGSK-3BETA INHIBITOR IIGSK2646264MERCAPTOPURINECDK/CRK INHIBITORAZATHIOPRINEGSK-3BETA INHIBITOR IVORUCICLIBFLUDARABINESB 216763ALSTERPAULLONE 2-CYANOETHYLLITHIUM CARBONATEGEMCITABINEPEGINTERFERON ALFA-2ACOMPOUND 2F [JIANG ET AL., 2018](7S)-2-(2-AMINOPYRIMIDIN-4-YL)-7-(2-FLUOROETHYL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONETECADENOSONPACLITAXELCYTARABINEMETHOTREXATEPEGINTERFERON ALFA-2BLIDOFLAZINEAZD1080ISOGRANULATIMIDERECOMBINANT INTERFERONCOMPOUND 2 [PMID: 22560567]COMPOUND 5B [PMID: 24900464]BX-912AZD2858CHIR-98014ASPIRINNITROBENZYLMERCAPTOPURINE RIBONUCLEOSIDEAR-AO-14418CDK1/5 INHIBITORTWS119N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINELY2090314GNF 4877COMPOUND 4-3 [PMID: 34027661]RGB-286638URIDINEALSTERPAULLONE1-AZAKENPAULLONEKENPAULLONEBX-795INDIRUBIN-3'-MONOXIMEELRAGLUSIBTRIFLURIDINEIM-12
Antibody
Interaction Protein
ENSG00000168961
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 28369848 | End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles. | No related sentences available |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No related sentences available |