Protein detail

SMO

Protein smoothened (Protein Gx)

Protein symbol
SMO
UniProt ID
Q99835
EVMP score
0.50
Frequency
1
Transmembrane count
7
Protein classification
Cancer-related genesDisease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPlasma proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Protein smoothened (Protein Gx)
Protein Class
Cancer-related genesDisease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Transporters
  • Human disease related genes:Cancers:Skin cancers
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Disease related genes
  • Cancer-related genes
  • G-protein coupled receptors:Family fz/smo receptors
  • FDA approved drug targets:Small molecule drugs
Transmembrane
234..254; Helical; Name=1; 263..283; Helical; Name=2; 315..335; Helical; Name=3; 359..379; Helical; Name=4; 403..423; Helical; Name=5; 452..472; Helical; Name=6; 525..545; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000128602
Entrez Gene Symbol
SMO
Gene Synonym
FZD11SMOH
Gene Description
Smoothened, frizzled class receptor
Chromosome
7
Position
129188633-129213545
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Transporters
  • Human disease related genes:Cancers:Skin cancers
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Disease related genes
  • Cancer-related genes
  • G-protein coupled receptors:Family fz/smo receptors
  • FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

54 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorHPMRNoYesNoYesNo
receptorreceptorCellTalkDBNoYesNoYesNo
receptorreceptorSurfaceomeNoYesNoYesNo
receptorreceptorRamilowski2015NoYesNoYesNo
receptorreceptorKirouac2010NoYesNoYesNo
gpcrreceptorDGIdbNoYesNoYesNo
receptorreceptorLRdbNoYesNoYesNo
receptorreceptorBaccin2019NoYesNoYesNo
frizzledreceptorAlmen2009NoYesNoYesNo
gpcrreceptorAlmen2009NoYesNoYesNo
Page 1 of 6Next

Regulatory Interaction Network

36 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
SMOQ99835EVCP57679YesYesNoSignaLink3SignaLink3:22986504
SMOQ99835LBNQ86UK5YesYesNoSignaLink3SignaLink3:22986504
ARBK1P25098SMOQ99835YesYesNoSPIKEWangSPIKE_LCSIGNORSIGNOR:21695114SIGNOR:15618519SPIKE_LC:15618519SIGNOR:23074268SPIKE:15618519
PTC1Q13635SMOQ99835YesYesYesWangNetPathSIGNORHPRDCui2007SignaLink3BioGRIDCancerCellMapSPIKE_LCSPIKESPIKE_LC:9811851SPIKE:20207148BioGRID:9811851HPRD:9811851SPIKE_LC:20207148SPIKE_LC:20076617NetPath:9811851SIGNOR:12192414SPIKE:20076617NetPath:8906787SIGNOR:14556242SPIKE:9811851SignaLink3:23331499CancerCellMap:9811851SignaLink3:14556242
PTC2Q9Y6C5SMOQ99835YesYesNoWangNetPathHPRDCui2007SignaLink3CancerCellMapSPIKE_LCSPIKESignaLink3:18988627SignaLink3:9811851SPIKE_LC:9811851HPRD:9811851NetPath:9811851SPIKE:9811851SignaLink3:23331499CancerCellMap:9811851
SMOQ99835ARRB2P32121YesYesNoWangNetPathSIGNORHINTSPIKE_LCSPIKENetPath:15618519SIGNOR:15618519SPIKE_LC:15618519SIGNOR:23074268SPIKE:15618519HINT:23877428HINT:15618519
GSK3BP49841SMOQ99835YesYesYesWangCui2007SignaLink3SignaLink3:15803137SignaLink3:23331499
SMOQ99835KAPCAP17612YesYesYesSignaLink3ACSNACSN:20956384ACSN:17688959ACSN:18820483SignaLink3:14611647ACSN:20643644ACSN:21209912ACSN:17641202ACSN:19592253SignaLink3:23331499ACSN:19549984ACSN:20016067ACSN:18997815
GRK6P43250SMOQ99835YesYesNoSignaLink3SignaLink3:15618519SignaLink3:23331499
ARRB1P49407SMOQ99835YesYesNoSignaLink3SignaLink3:15618519SignaLink3:23331499
Page 1 of 4Next

Protein Complex Composition

18 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CDC5LCRNKL1CYP3A5EFTUD2HSPA8PRPF8SMN1SMOXSNRPASNRPA1SNRPD2SNW1P09012P09661P11142P20815P62316Q13573Q15029Q16637Q6P2Q9Q99459Q9BZJ0Q9NWM01:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC9140
DDRGK1IMMTMSMO1PDHA2YARS2P29803Q15800Q16891Q96HY6Q9Y2Z40:0:0:0:0Havugimana2012Havugimana2012:C_454
EVCSMOP57679Q998350:0KEGG-MEDICUS
ENTREP3HECW1SMOP81408Q76N89Q998350:0:0hu.MAP2
GPR180MSMO1Q15800Q86V850:0hu.MAP
CRBNKDM4DSMOC1TRPC4APQ6B0I6Q8TEL6Q96SW2Q9H4F80:0:0:0hu.MAP2
KDM4DSMOC1TRPC4APQ6B0I6Q8TEL6Q9H4F80:0:0hu.MAP2
SMOQ998352PDBPDB:5l7dPDB:5v57PDB:7zi0PDB:4jkvPDB:5v56PDB:5l7i
Page 2 of 2Previous

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometry9309501852839651134623918377869183481790628986585278941043832153532089743
Sequence, Structure & Domains

Sequences

Length
787
Mass
86,397
Sequence
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF

3D Structural Models

Turn
152..154; 165..167; 171..173; 182..184; 262..265; 354..356; 385..388
Helix
62..64; 99..109; 110..113; 116..130; 144..151; 155..160; 203..205; 224..254; 256..259; 266..282; 283..285; 289..294; 313..347; 361..378; 397..403; 405..432; 443..492; 515..532; 533..536; 539..548
Beta Strand
65..67; 76..78; 86..88; 90..92; 136..140; 176..178; 190..192; 197..199; 210..218; 299..301; 304..306; 308..310; 381..384; 389..395; 436..442; 496..498; 501..503; 554..558
3D Structure
Electron microscopy (5); X-ray crystallography (10)

Domain & Motif Annotations

Compositional Bias
38..53; Low complexity; 668..680; Basic residues; 685..699; Pro residues
Domain (CC)
The N-terminal extracellular domain mediates sterol-binding which is required for maximal activation of signaling (PubMed:24859340). Contains a second sterol-binding site within the seven-transmembrane pocket which is also required for activation (By similarity). The activating sterol is likely to be cholesterol (PubMed:35658032). The extracellular site is required for SHH-induced activity while the site within the transmembrane pocket regulates basal signaling in the absence of SHH (PubMed:35658032).
Domain (FT)
65..181; FZ
Region
30..60; Disordered; 538..569; Interaction with BBS5 and BBS7; 570..653; Required for interaction with PRKACA; 581..593; Interaction with DLG5; 667..704; Disordered
Protein Families
G-protein coupled receptor Fz/Smo family
Sequence Similarities
Belongs to the G-protein coupled receptor Fz/Smo family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Related Diseases
Basal cell carcinomaBrain cancerChronic myelomonocytic leukaemiaOvarian cancerSkin cancerSolid tumour/cancer
Biomarker
Approved; Phase 2; Phase 1
Drug Targets
FDA approved drug targets
Drugs
TALADEGIBGLASDEGIBVISMODEGIBSONIDEGIBPATIDEGIBNULLGEFITINIBARSENIC TRIOXIDETAK-441GLASDEGIB MALEATEBMS-833923PURMORPHAMINELEQ506
Antibody
CAB011446CAB080590