Protein detail
HAUS7
HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) (X-linked protein STS1769)
Protein symbol HAUS7 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) (X-linked protein STS1769)
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificEnteric stem cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-5620912 anchoring of the basal body to the plasma membrane
- R-hsa-8854518 aurka activation by tpx2
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-5617833 cilium assembly
- R-hsa-453274 mitotic g2 g2 m phases
- R-hsa-68877 mitotic prometaphase
- R-hsa-68886 m phase
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-380270 recruitment of mitotic centrosome proteins and complexes
- R-hsa-380320 recruitment of numa to mitotic centrosomes
- R-hsa-2565942 regulation of plk1 activity at g2 m transition
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
9 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 24069378 |
Sequence, Structure & Domains
Sequences
Length
358
Mass
39,794
Sequence
MAGQDAGCGRGGDDYSEDEGDSSVSRAAVEVFGKLKDLNCPFLEGLYITEPKTIQELLCSPSEYRLEILEWMCTRVWPSLQDRFSSLKGVPTEVKIQEMTKLGHELMLCAPDDQELLKGCACAQKQLHFMDQLLDTIRSLTIGCSSCSSLMEHFEDTREKNEALLGELFSSPHLQMLLNPECDPWPLDMQPLLNKQSDDWQWASASAKSEEEEKLAELARQLQESAAKLHALRTEYFAQHEQGAAAGAADISTLDQKLRLVTSDFHQLILAFLQVYDDELGECCQRPGPDLHPCGPIIQATHQNLTSYSQLLQVVMAVADTSAKAVETVKKQQGEQICWGGSSSVMSLATKMNELMEK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99871-1; Sequence=Displayed; Name=2; IsoId=Q99871-2; Sequence=VSP_037669; Name=3; IsoId=Q99871-3; Sequence=VSP_040920, VSP_040921
Alternative Sequence
310; Q -> QIPRGQPKKPALVTMTTVPTCATLPLAQGFRDVHFGFLSERLRAFQPLTGWSCETPRSGM (in isoform 2); 311..329; LLQVVMAVADTSAKAVETV -> VRVPFPSPLTAPSPVHSD (in isoform 3); 330..358; Missing (in isoform 3)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
1..10; Gly residues
Coiled Coil
203..236
Region
1..20; Disordered
Protein Families
HAUS7 family
Sequence Similarities
Belongs to the HAUS7 family.
Clinical Relevance
Interaction Protein
ENSG00000137814ENSG00000147874ENSG00000152240
Interaction Count
3
Interaction Dataset
intact_biogrid