Protein detail

SC6A7

Sodium-dependent proline transporter (Solute carrier family 6 member 7)

Entry name
SC6A7
UniProt ID
Q99884
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
12
Protein classification
Metabolic proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Sodium-dependent proline transporter (Solute carrier family 6 member 7)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
46..66; Helical; Name=1; 74..93; Helical; Name=2; 117..137; Helical; Name=3; 215..233; Helical; Name=4; 242..259; Helical; Name=5; 295..312; Helical; Name=6; 324..345; Helical; Name=7; 378..397; Helical; Name=8; 425..443; Helical; Name=9; 459..479; Helical; Name=10; 500..519; Helical; Name=11; 538..556; Helical; Name=12
Transmembrane Count
12
Ensembl
ENSG00000011083
Entrez Gene Symbol
SLC6A7
Gene Synonym
PROT
Gene Description
Solute carrier family 6 member 7
Chromosome
5
Position
150190062-150222788
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificCytotrophoblasts
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
KEGG
hsa04721 Synaptic vesicle cycle
Reactome (5)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence16

Ligand-Receptor Signaling (15)

15 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
transportertransporterSurfaceomeYes
slc6transporterSurfaceomeYes
slctransporterSurfaceomeYes
transportertransporterOmniPathYes
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains

Sequences

Length
636
Mass
70,911
Sequence
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM

Domain & Motif Annotations

Protein Families (2)
  • Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
  • SLC6A7 subfamily
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily.
Clinical Relevance
Antibody (2)
HPA028907HPA063773
Supporting Publications2
PMIDTitleRelated sentences
37322475Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available