Protein detail
SC6A7
Sodium-dependent proline transporter (Solute carrier family 6 member 7)
Entry name SC6A7 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium-dependent proline transporter (Solute carrier family 6 member 7)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
46..66; Helical; Name=1; 74..93; Helical; Name=2; 117..137; Helical; Name=3; 215..233; Helical; Name=4; 242..259; Helical; Name=5; 295..312; Helical; Name=6; 324..345; Helical; Name=7; 378..397; Helical; Name=8; 425..443; Helical; Name=9; 459..479; Helical; Name=10; 500..519; Helical; Name=11; 538..556; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
PROT
Gene Description
Solute carrier family 6 member 7
Chromosome
5
Position
150190062-150222788
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificCytotrophoblasts
Function & Pathway7
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Reactome (5)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence16
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| slc6 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains5
Sequences
Length
636
Mass
70,911
Sequence
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
Domain & Motif Annotations
Protein Families (2)
- Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
- SLC6A7 subfamily
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily.
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |