Protein detail

GBRG3

Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3)

Entry name GBRG3	UniProt ID Q99928	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3)

Protein Class (3)

FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Transmembrane

257..277; Helical; 284..303; Helical; 312..332; Helical; 447..467; Helical

Transmembrane Count

Ensembl

ENSG00000182256

Entrez Gene Symbol

GABRG3

Gene Description

Gamma-aminobutyric acid type A receptor subunit gamma3

Chromosome

Position

26971181-27541984

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Cellular Component (12)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

KEGG (7)

Reactome (6)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence30

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	No	No
gaba_ach	receptor	Almen2009	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
cys_loop	transporter	Surfaceome	No	Yes	No	No	No
channels	transporter	Surfaceome	No	Yes	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No

Page 1 of 3Next

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	38014595 30915084

Sequence, Structure & Domains8

Sequences

Length

467

Mass

54,289

Sequence

MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99928-1; Sequence=Displayed; Name=2; IsoId=Q99928-2; Sequence=VSP_047543, VSP_047544

Alternative Sequence

239..253; DYVVMTIYFELSRRM -> RNLLKEAQLSKAREA (in isoform 2); 254..467; Missing (in isoform 2)

Domain & Motif Annotations

Domain (CC)

GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Protein Families (3)

Ligand-gated ion channel (TC 1.A.9) family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
GABRG3 sub-subfamily

Sequence Similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily.

Clinical Relevance6

Disease Involvement

FDA approved drug targets

Biomarker

Terminated; Approved; Investigative; Phase 3; Phase 2; Discontinued in Phase 1

Drug Targets

FDA approved drug targets

Drugs (86)

FLURAZEPAM CIPEPOFOL CHLORDIAZEPOXIDE HYDROCHLORIDE PRAZEPAM PROPOFOL NULL CHLORMETHIAZOLE DARIGABAT GANAXOLONE ZURANOLONE HALAZEPAM BUTABARBITAL SODIUM CENOBAMATE CLONAZEPAM CINOLAZEPAM DIMDAZENIL DIAZEPAM QUAZEPAM TRIAZOLAM ESTAZOLAM FLUDIAZEPAM LORAZEPAM MIDAZOLAM HYDROCHLORIDE BREXANOLONE PAGOCLONE FLUMAZENIL ACAMPROSATE CALCIUM CLORAZEPATE TEMAZEPAM CHLORDIAZEPOXIDE THIAMYLAL SODIUM PENTOBARBITAL SODIUM ETOMIDATE METHARBITAL MEBUTAMATE STIRIPENTOL ETHCHLORVYNOL METHOHEXITAL SODIUM METHAQUALONE HYDROCHLORIDE NITRAZEPAM ALPRAZOLAM BUTALBITAL ISOFLURANE PRIMIDONE ESZOPICLONE TOPIRAMATE CLOBAZAM ADIPIPLON THIAMYLAL FLUNITRAZEPAM TETRAZEPAM TALBUTAL AZD-3043 ADINAZOLAM CLORAZEPATE DIPOTASSIUM DESFLURANE TRICLOFOS SODIUM THIOPENTAL SODIUM OXAZEPAM ORG-25435 ETIFOXINE BENTAZEPAM METHYPRYLON HALOTHANE REMIMAZOLAM METHOXYFLURANE ZOLPIDEM TARTRATE SARIPIDEM BROMAZEPAM ABP-700 CLOTIAZEPAM ARBACLOFEN PLACARBIL MEPROBAMATE LOREDIPLON OCINAPLON [3H]AZIETOMIDATE ENFLURANE RESEQUINIL REMIMAZOLAM BESYLATE METHAQUALONE GLUTETHIMIDE FLURAZEPAM HYDROCHLORIDE ETAZOLATE SEVOFLURANE SECOBARBITAL SODIUM PADSEVONIL

Antibody

HPA054010

Supporting Publications1

PMID	Title	Abstract
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available