Protein detail
GBRG3
Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3)
Protein symbol GBRG3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3)
Protein Class
FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
257..277; Helical; 284..303; Helical; 312..332; Helical; 447..467; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Gamma-aminobutyric acid type A receptor subunit gamma3
Chromosome
15
Position
26971181-27541984
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component
- GO:0005730 nucleolus
- GO:0005886 plasma membrane
- GO:0015630 microtubule cytoskeleton
- GO:0032590 dendrite membrane
- GO:0034707 chloride channel complex
- GO:0043005 neuron projection
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0098794 postsynapse
- GO:0098982 GABA-ergic synapse
- GO:1902495 transmembrane transporter complex
- GO:1902711 GABA-A receptor complex
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | No | No |
| gaba | receptor | HGNC | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
467
Mass
54,289
Sequence
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99928-1; Sequence=Displayed; Name=2; IsoId=Q99928-2; Sequence=VSP_047543, VSP_047544
Alternative Sequence
239..253; DYVVMTIYFELSRRM -> RNLLKEAQLSKAREA (in isoform 2); 254..467; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
- GABRG3 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Alzheimer diseaseAnxiety disorderCorneal diseaseDepressionEpilepsy/seizureFemale pelvic painFragile X chromosomeGeneral pain disorderInsomniaIntentional self-harmIschaemic/haemorrhagic strokeLabour/delivery anaesthesia complicationMental/behavioural/neurodevelopmental disorderMood/affect symptomNeurodegenerative disorderPainPanic disorderParkinsonismPostoperative inflammationStatus epilepticusSubstance abuseTremor-related disorder
Biomarker
Terminated; Approved; Investigative; Phase 3; Phase 2; Discontinued in Phase 1
Drug Targets
FDA approved drug targets
Drugs
FLURAZEPAMCIPEPOFOLCHLORDIAZEPOXIDE HYDROCHLORIDEPRAZEPAMPROPOFOLNULLCHLORMETHIAZOLEDARIGABATGANAXOLONEZURANOLONEHALAZEPAMBUTABARBITAL SODIUMCENOBAMATECLONAZEPAMCINOLAZEPAMDIMDAZENILDIAZEPAMQUAZEPAMTRIAZOLAMESTAZOLAMFLUDIAZEPAMLORAZEPAMMIDAZOLAM HYDROCHLORIDEBREXANOLONEPAGOCLONEFLUMAZENILACAMPROSATE CALCIUMCLORAZEPATETEMAZEPAMCHLORDIAZEPOXIDETHIAMYLAL SODIUMPENTOBARBITAL SODIUMETOMIDATEMETHARBITALMEBUTAMATESTIRIPENTOLETHCHLORVYNOLMETHOHEXITAL SODIUMMETHAQUALONE HYDROCHLORIDENITRAZEPAMALPRAZOLAMBUTALBITALISOFLURANEPRIMIDONEESZOPICLONETOPIRAMATECLOBAZAMADIPIPLONTHIAMYLALFLUNITRAZEPAMTETRAZEPAMTALBUTALAZD-3043ADINAZOLAMCLORAZEPATE DIPOTASSIUMDESFLURANETRICLOFOS SODIUMTHIOPENTAL SODIUMOXAZEPAMORG-25435ETIFOXINEBENTAZEPAMMETHYPRYLONHALOTHANEREMIMAZOLAMMETHOXYFLURANEZOLPIDEM TARTRATESARIPIDEMBROMAZEPAMABP-700CLOTIAZEPAMARBACLOFEN PLACARBILMEPROBAMATELOREDIPLONOCINAPLON[3H]AZIETOMIDATEENFLURANERESEQUINILREMIMAZOLAM BESYLATEMETHAQUALONEGLUTETHIMIDEFLURAZEPAM HYDROCHLORIDEETAZOLATESEVOFLURANESECOBARBITAL SODIUMPADSEVONIL
Antibody