Protein detail
KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3 (Delayed-rectifier K(+) channel alpha subunit 3) (Delayed-rectifier potassium channel subunit Kv9.3) (Kv9.3) (Potassium voltage-gated channel subfamily S member 3)
Entry name KCNS3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count 6 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Delayed-rectifier potassium channel regulatory subunit KCNS3 (Delayed-rectifier K(+) channel alpha subunit 3) (Delayed-rectifier potassium channel subunit Kv9.3) (Kv9.3) (Potassium voltage-gated channel subfamily S member 3)
Protein Class (4)
Predicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function (3)
- Transporters:Transporter channels and pores
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
- Predicted intracellular proteins
Transmembrane
183..204; Helical; Name=Segment S1; 221..243; Helical; Name=Segment S2; 255..275; Helical; Name=Segment S3; 286..306; Helical; Voltage-sensor; Name=Segment S4; 322..343; Helical; Name=Segment S5; 385..413; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
Kv9.3
Gene Description
Potassium voltage-gated channel modifier subfamily S member 3
Chromosome
2
Position
17877847-18361616
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Function & Pathway6
Protein Function (3)
- Transporters:Transporter channels and pores
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Reactome (6)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence24
Ligand-Receptor Signaling (23)
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 3 of 3Previous
Sequence, Structure & Domains7
Sequences
Length
491
Mass
56,001
Sequence
MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK
Domain & Motif Annotations
Motif
370..375; Selectivity filter
Domain (CC)
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Protein Families (3)
- Potassium channel family
- S (TC 1.A.1.2) subfamily
- Kv9.3/KCNS3 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
Clinical Relevance2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37022097 | Extracellular Vesicle ITGAM and ITGB2 Mediate Severe Acute Pancreatitis-Related Acute Lung Injury. | No abstract available |