Protein detail

PD1L2

Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)

Entry name PD1L2	UniProt ID Q9BQ51	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 1	Protein classification Cancer-related genesCD markersPredicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)

Protein Class (4)

Cancer-related genesCD markersPredicted membrane proteinsPredicted secreted proteins

Protein Function (3)

Predicted secreted proteins
CD markers
Cancer-related genes

Transmembrane

221..241; Helical

Transmembrane Count

Ensembl

ENSG00000197646

Entrez Gene Symbol

PDCD1LG2

Gene Synonym (6)

B7-DCbA574F11.2BtdcCD273PD-L2PDL2

Gene Description

Programmed cell death 1 ligand 2

Chromosome

Position

5510531-5571282

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Cell SpecificNeutrophilsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificneutrophil

Function & Pathway7

Protein Function (3)

Predicted secreted proteins
CD markers
Cancer-related genes

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

KEGG

hsa04514 Cell adhesion molecule (CAM) interaction

Reactome (6)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence53

Ligand-Receptor Signaling (51)

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	Yes	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	Yes	Yes	No
b7_family	cell_surface_ligand	HGNC	Yes	No	Yes	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AUNIP BCS1L PDCD1LG2	Q9BQ51 Q9H7T9 Q9Y276	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	28986585 27894104

Sequence, Structure & Domains11

Sequences

Length

273

Mass

30,957

Sequence

MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PD-L2I, Type I; IsoId=Q9BQ51-1; Sequence=Displayed; Name=2; Synonyms=PD-L2II, Type II; IsoId=Q9BQ51-2; Sequence=VSP_013740; Name=3; Synonyms=PD-L2III, Type III; IsoId=Q9BQ51-3; Sequence=VSP_013738, VSP_013739

Alternative Sequence

121..211; ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQS -> G (in isoform 2); 121..182; ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRL -> DGTQDPSNLAASHFHPLLHHCFHFHSHSDSPKKTTLSKAVFFKRHNKKTCHHNKEGSEQCYL (in isoform 3); 183..273; Missing (in isoform 3)

3D Structural Models

Helix

77..82; 94..96; 220..250

Beta Strand

22..24; 29..33; 38..45; 53..62; 84..91; 98..106; 109..120

3D Structure

NMR spectroscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

21..118; Ig-like V-type; 122..203; Ig-like C2-type

Protein Families (2)

Immunoglobulin superfamily
BTN/MOG family

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Clinical Relevance3

Disease Involvement

Cancer-related genes

Drugs (2)

PEMBROLIZUMAB RHIGM12B7

Antibody

HPA013411

Supporting Publications3

PMID	Title	Abstract
35366112	Programmed death receptor ligand-2 (PD-L2) bearing extracellular vesicles as a new biomarker to identify early triple-negative breast cancer patients at high risk for relapse.	Based on the tumor-promoting features of extracellular vesicles (EV) and PD-L1/2-bearing EV subpopulations (PD-L1/2 After enrichment of EV from plasma samples of 56 patients before and 50 after chemotherapy (CT), we determined levels of EV particle number and PD-L1/2 Compared to healthy controls, patients had a tenfold higher EV concentration and significantly elevated PD L2 This study highlights PD L2 © 2022.
37547182	Retroviral b-Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation.	For the very first time, we demonstrate a unique elevated presence of several stimulatory (CD27, CD28, 4-1BB) and inhibitory (BTLA, CTLA-4, LAG-3, PD-1, PD-L2) ICP receptors in HAM/TSP sera, and in purified exosomes from a HAM/TSP-derived HTLV-1-producing (OSP2) cells.
39304856	Type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from head and neck cancer patients.	Furthermore, we observed a significant type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from HNSCC patients, which could be visualized by fluorescence microcopy of membrane stained exosomes. Our data revealed elevated overall plasma levels of CTLA-4, PD-L1, and TIM-3 as well as elevated exosome-associated CTLA-4, PD-L2, TIM-3, and LAG-3 levels in HNSCC patients compared to HD.