Protein detail

PSD2

PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2)

Entry name
PSD2
UniProt ID
Q9BQI7
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
1
Protein classification
Basic Information
Protein Names
PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2)
Protein Function
Predicted intracellular proteins
Transmembrane
622..639; Helical
Transmembrane Count
1
Ensembl
ENSG00000146005
Entrez Gene Symbol
PSD2
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
PSD2 fluorescence
Cell SpecificMast cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
KEGG
hsa04144 Endocytosis
Mediation Categories
Receptor-signaling mediation
Relations & Evidence13

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
plasma_membraneplasma_membraneUniProt_location
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationWestern blottingFlow cytometry138321535
Sequence, Structure & Domains

Sequences

Length
771
Mass
84,660
Sequence
MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEPTKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAEDPQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPLTPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIKVGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT

Domain & Motif Annotations

Compositional Bias
47..66; Basic and acidic residues; 218..230; Low complexity; 257..266; Acidic residues; 288..299; Low complexity; 748..761; Polar residues
Coiled Coil
651..680
Domain (FT)
260..462; SEC7; 512..625; PH
Region
1..67; Disordered; 107..136; Disordered; 207..230; Disordered; 244..307; Disordered; 739..771; Disordered
Protein Families
PSD family
Sequence Similarities
Belongs to the PSD family.
Supporting Publications2
PMIDTitleRelated sentences
37430307Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression.Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression.
39015940Dynamic nanomechanical characterization of cells in exosome therapy.Further experiments revealed that exosomes enhance the traction force and cytoskeleton by regulating the Rac1/RhoA signaling pathway, thereby promoting cell proliferation.