EV MemProt Atlas

Basic Information

Protein Names

Hephaestin (Hp) (EC 1.16.3.1)

Protein Class

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

1111..1131; Helical

Transmembrane Count

1

Ensembl

ENSG00000089472

Entrez Gene Symbol

HEPH

Gene Synonym

CPLKIAA0698

Gene Description

Hephaestin

Chromosome

X

Position

66162671-66268867

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificEsophageal apical cellsBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
basolateral_cell_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
basolateral_cell_membrane	plasma_membrane	LOCATE	No	No	No	Yes	No
plasma_membrane	plasma_membrane	LOCATE	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATG9B CRYBG1 FBXL4 HEPHL1 PLCD1	P51178 Q674R7 Q6MZM0 Q9UKA2 Q9Y4K1	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	2	34265469 39996590

Sequence, Structure & Domains

Sequences

Length

1,158

Mass

130,449

Sequence

MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BQS7-1; Sequence=Displayed; Name=2; IsoId=Q9BQS7-2; Sequence=VSP_011627; Name=3; IsoId=Q9BQS7-3; Sequence=VSP_047331; Name=4; IsoId=Q9BQS7-4; Sequence=VSP_047332

Alternative Sequence

1..267; Missing (in isoform 4); 1; M -> MTQTLPYHLSLLNVLFPGPCSRHFKFRRGKCAQPAWRKVSAPSQDLLITKVMWAM (in isoform 3); 1082; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (FT)

24..206; Plastocyanin-like 1; 218..366; Plastocyanin-like 2; 370..560; Plastocyanin-like 3; 570..718; Plastocyanin-like 4; 731..903; Plastocyanin-like 5; 911..1067; Plastocyanin-like 6

Protein Families

Multicopper oxidase family

Sequence Similarities

Belongs to the multicopper oxidase family.

Clinical Relevance

Antibody

HPA005824

Protein symbol HEPH	UniProt ID Q9BQS7	EVMP score 0.38
Frequency	Transmembrane count 1	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters