Protein detail
RHXF2
Rhox homeobox family member 2 (Paired-like homeobox protein PEPP-2) (Testis homeobox gene 1)
Entry name RHXF2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTranscription factors |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Rhox homeobox family member 2 (Paired-like homeobox protein PEPP-2) (Testis homeobox gene 1)
Protein Class (2)
Predicted intracellular proteinsTranscription factors
Protein Function (2)
- Transcription factors:Helix-turn-helix domains
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CT107PEPP-2PEPP2THG1
Gene Description
Rhox homeobox family member 2
Chromosome
X
Position
120158613-120165630
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization6
Tissue SpecificepididymisCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmemory B-cellSecretome LocationSecreted to bloodSecretome FunctionEnzyme
Function & Pathway5
Protein Function (2)
- Transcription factors:Helix-turn-helix domains
- Predicted intracellular proteins
Cellular Component (2)
Molecular Function (5)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence7
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryWestern blottingR SequencingFlow cytometryMORPHELISA | 11 | 3994949039873726387318682680191927894104383215353849095840098346386984203132059138136601 |
Sequence, Structure & Domains8
Sequences
Length
288
Mass
31,692
Sequence
MEPPDQCSQYMTSLLSPAVDDEKELQDMNAMVLSLTEEVKEEEEDAQPEPEQGTAAGEKLKSAGAQGGEEKDGGGEEKDGGGAGVPGHLWEGDLEGTSGSDGNVEDSDQSEKEPGQQYSRPQGAVGGLEPGNAQQPNVHAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQRALMARNMLPFMAVGQPVMVTAAEAITAPLFISGMRDDYFWDHSHSSSLCFPMPPFPPPSLPLPLMLLPPMPPAGQAEFGPFPFVIVPSFTFPNV
Domain & Motif Annotations
Compositional Bias
39..48; Acidic residues; 68..80; Basic and acidic residues
Motif
186..195; Nuclear localization signal
Region
16..136; Disordered
Protein Families (2)
- Paired-like homeobox family
- PEPP subfamily
Sequence Similarities
Belongs to the paired-like homeobox family. PEPP subfamily.
Clinical Relevance4
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |