Protein detail

COR1B

Coronin-1B (Coronin-2)

Entry name COR1B	UniProt ID Q9BR76	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Coronin-1B (Coronin-2)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000172725

Entrez Gene Symbol

CORO1B

Gene Synonym

coronin-2

Gene Description

Coronin 1B

Chromosome

Position

67435510-67443821

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue Specificheart muscleCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificastrocyte

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (12)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

Canonical Pathways (3)

M229 Pid p38 alpha beta downstream pathway
M12 Pid rhoa pathway
M8 Pid endothelin pathway

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence19

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CORO1B	PRKCA	P17252	S	2	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:16027158 HPRD:16027158 KEA:16027158
CORO1B	SSH1	Q8WYL5	S	2	dephosphorylation	DEPOD	DEPOD:17350576
CORO1B	SSH1	Q8WYL5	S	2	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:17350576
CORO1B	MAPK14	Q16539	S	2	phosphorylation	RLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:27592029
CORO1B	PRKCE	Q02156	S	2	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
actin_regulation_adhesome	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SSH1	Q8WYL5	COR1B	Q9BR76	Yes	Yes	No	AdhesomeSIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper	DEPOD:17350576 ProtMapper:17350576 SIGNOR:17350576 Adhesome:17350576 HPRD:17350576
KPCA	P17252	COR1B	Q9BR76	Yes	No	Yes	AdhesomeMIMPPhosphoSite_MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	ProtMapper:16027158 HPRD-phos:16027158 HINT:17350576 Adhesome:17350576 Adhesome:16027158 SIGNOR:16027158 HPRD:17350576 HINT:16027158 HPRD:16027158 KEA:16027158
MK14	Q16539	COR1B	Q9BR76	Yes	No	No	iPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:22619279 ProtMapper:27592029 PhosphoSite:16027158 PhosphoSite:17350576 PhosphoSite:33275893 PhosphoSite:27592029

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CORO1B CWC27 UNC119B	A6NIH7 Q6UX04 Q9BR76	0:0:0	hu.MAP
CORO1B MYL1 NUP107 TP53BP1	P05976 P57740 Q12888 Q9BR76	0:0:0:0	Havugimana2012	Havugimana2012:C_384
CORO1A CORO1B	P31146 Q9BR76	0:0	hu.MAP2
AK2 CORO1B EPPK1 SAFB TELO2	P54819 P58107 Q15424 Q9BR76 Q9Y4R8	0:0:0:0:0	Havugimana2012	Havugimana2012:C_483

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	1	34473505

Sequence, Structure & Domains9

Sequences

Length

489

Mass

54,235

Sequence

MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMAPGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQLGRMENGDA

Domain & Motif Annotations

Compositional Bias

428..441; Low complexity

Repeat

18..72; WD 1; 73..122; WD 2; 123..166; WD 3; 167..210; WD 4; 211..256; WD 5; 257..296; WD 6

Coiled Coil

449..474

Region

408..444; Disordered

Protein Families

WD repeat coronin family

Sequence Similarities

Belongs to the WD repeat coronin family.

Clinical Relevance4

Antibody (3)

CAB017616 HPA040113 HPA070456

Interaction Protein (4)

ENSG00000102879ENSG00000110880ENSG00000114446ENSG00000143799

Interaction Count

Interaction Dataset (4)

biogrid_bioplexintact_biogrid_opencell_bioplexintact_biogridbiogrid_opencell

Supporting Publications2

PMID	Title	Abstract
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available
36394150	A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer.	No abstract available