Protein detail
COR1B
Coronin-1B (Coronin-2)
Entry name COR1B | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Coronin-1B (Coronin-2)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
coronin-2
Gene Description
Coronin 1B
Chromosome
11
Position
67435510-67443821
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (12)
- GO:0001725 stress fiber
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0030027 lamellipodium
- GO:0031252 cell leading edge
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
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Molecular Function (5)
Biological Process (3)
Canonical Pathways (3)
- M229 Pid p38 alpha beta downstream pathway
- M12 Pid rhoa pathway
- M8 Pid endothelin pathway
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence19
Enzyme-Mediated Modification (5)
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CORO1B | PRKCA | P17252 | S | 2 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16027158HPRD:16027158KEA:16027158 |
| CORO1B | SSH1 | Q8WYL5 | S | 2 | dephosphorylation | DEPOD | DEPOD:17350576 |
| CORO1B | SSH1 | Q8WYL5 | S | 2 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:17350576 |
| CORO1B | MAPK14 | Q16539 | S | 2 | phosphorylation | RLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:27592029 |
| CORO1B | PRKCE | Q02156 | S | 2 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | ||||
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SSH1 | Q8WYL5 | COR1B | Q9BR76 | Yes | Yes | AdhesomeSIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper | DEPOD:17350576ProtMapper:17350576SIGNOR:17350576Adhesome:17350576HPRD:17350576 | |
| KPCA | P17252 | COR1B | Q9BR76 | Yes | Yes | AdhesomeMIMPPhosphoSite_MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper | ProtMapper:16027158HPRD-phos:16027158HINT:17350576Adhesome:17350576Adhesome:16027158SIGNOR:16027158HPRD:17350576HINT:16027158HPRD:16027158KEA:16027158 | |
| MK14 | Q16539 | COR1B | Q9BR76 | Yes | iPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:22619279ProtMapper:27592029PhosphoSite:16027158PhosphoSite:17350576PhosphoSite:33275893PhosphoSite:27592029 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CORO1BCWC27UNC119B | A6NIH7Q6UX04Q9BR76 | 0:0:0 | hu.MAP | |||
| CORO1BMYL1NUP107TP53BP1 | P05976P57740Q12888Q9BR76 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_384 | ||
| CORO1ACORO1B | P31146Q9BR76 | 0:0 | hu.MAP2 | |||
| AK2CORO1BEPPK1SAFBTELO2 | P54819P58107Q15424Q9BR76Q9Y4R8 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_483 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 1 | 34473505 |
Sequence, Structure & Domains
Sequences
Length
489
Mass
54,235
Sequence
MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMAPGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQLGRMENGDA
Domain & Motif Annotations
Compositional Bias
428..441; Low complexity
Repeat
18..72; WD 1; 73..122; WD 2; 123..166; WD 3; 167..210; WD 4; 211..256; WD 5; 257..296; WD 6
Coiled Coil
449..474
Region
408..444; Disordered
Protein Families
WD repeat coronin family
Sequence Similarities
Belongs to the WD repeat coronin family.
Clinical Relevance
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 31382537 | An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers. | No related sentences available |
| 36394150 | A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer. | No related sentences available |