Protein detail
MXRA8
Matrix remodeling-associated protein 8 (Limitrin)
Entry name MXRA8 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Matrix remodeling-associated protein 8 (Limitrin)
Protein Class
Predicted membrane proteins
Transmembrane
342..362; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp586E2023
Gene Description
Matrix remodeling associated 8
Chromosome
1
Position
1352689-1361777
Supporting publications (n)
3
EVMP confidence score
0.25
Fluorescence & Localization4
Tissue Specificblood vesselCell SpecificEpididymal principal cellsSingle-Nuclei Brain Specificfibroblast
Function & Pathway7
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
Reactome (2)
Canonical Pathways (2)
- M12 Pid rhoa pathway
- M8 Pid endothelin pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence29
Ligand-Receptor Signaling (28)
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blottingMass spectrometry [LTQ-FT Ultra] | 1 | 34656547 |
Sequence, Structure & Domains13
Sequences
Length
442
Mass
49,132
Sequence
MALPSRILLWKLVLLQSSAVLLHSGSSVPAAAGSSVVSESAVSWEAGARAVLRCQSPRMVWTQDRLHDRQRVLHWDLRGPGGGPARRLLDLYSAGEQRVYEARDRGRLELSASAFDDGNFSLLIRAVEETDAGLYTCNLHHHYCHLYESLAVRLEVTDGPPATPAYWDGEKEVLAVARGAPALLTCVNRGHVWTDRHVEEAQQVVHWDRQPPGVPHDRADRLLDLYASGERRAYGPLFLRDRVAVGADAFERGDFSLRIEPLEVADEGTYSCHLHHHYCGLHERRVFHLTVAEPHAEPPPRGSPGNGSSHSGAPGPDPTLARGHNVINVIVPESRAHFFQQLGYVLATLLLFILLLVTVLLAARRRRGGYEYSDQKSGKSKGKDVNLAEFAVAAGDQMLYRSEDIQLDYKNNILKERAELAHSPLPAKYIDLDKGFRKENCK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BRK3-1; Sequence=Displayed; Name=2; IsoId=Q9BRK3-2; Sequence=VSP_027448, VSP_027449; Name=3; IsoId=Q9BRK3-3; Sequence=VSP_054528; Name=4; IsoId=Q9BRK3-4; Sequence=VSP_054529
Alternative Sequence
1..17; MALPSRILLWKLVLLQS -> MIRCAATG (in isoform 3); 25..125; Missing (in isoform 4); 407; L -> LASSPPT (in isoform 2); 435..442; GFRKENCK -> DPSGLCPLGA (in isoform 2)
3D Structural Models
Turn
66..68; 103..107; 142..144; 191..193; 237..241; 247..250; 277..280
Helix
57..59; 114..117; 129..131; 264..266
Beta Strand
36..39; 42..44; 50..52; 69..77; 86..95; 97..102; 108..110; 122..126; 133..140; 151..160; 170..180; 182..184; 204..209; 220..228; 242..245; 257..261; 268..275; 284..291
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
252..254; RGD
Domain (CC)
The RGD motif is involved in integrin ITGAV:ITGB3 binding.
Domain (FT)
29..157; Ig-like V-type 1; 160..288; Ig-like V-type 2
Region
294..318; Disordered
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 36114323 | Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment. | No abstract available |
| 39363010 | Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons. | No abstract available |
| 40595564 | Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome. | No abstract available |