Protein detail
MXRA8
Matrix remodeling-associated protein 8 (Limitrin)
Protein symbol MXRA8 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Basic Information
Protein Names
Matrix remodeling-associated protein 8 (Limitrin)
Protein Class
Predicted membrane proteins
Transmembrane
342..362; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp586E2023
Gene Description
Matrix remodeling associated 8
Chromosome
1
Position
1352689-1361777
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificEpididymal principal cellsSingle-Nuclei Brain Specificfibroblast
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M12 Pid rhoa pathway
- M8 Pid endothelin pathway
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blottingMass spectrometry [LTQ-FT Ultra] | 1 | 34656547 |
Sequence, Structure & Domains
Sequences
Length
442
Mass
49,132
Sequence
MALPSRILLWKLVLLQSSAVLLHSGSSVPAAAGSSVVSESAVSWEAGARAVLRCQSPRMVWTQDRLHDRQRVLHWDLRGPGGGPARRLLDLYSAGEQRVYEARDRGRLELSASAFDDGNFSLLIRAVEETDAGLYTCNLHHHYCHLYESLAVRLEVTDGPPATPAYWDGEKEVLAVARGAPALLTCVNRGHVWTDRHVEEAQQVVHWDRQPPGVPHDRADRLLDLYASGERRAYGPLFLRDRVAVGADAFERGDFSLRIEPLEVADEGTYSCHLHHHYCGLHERRVFHLTVAEPHAEPPPRGSPGNGSSHSGAPGPDPTLARGHNVINVIVPESRAHFFQQLGYVLATLLLFILLLVTVLLAARRRRGGYEYSDQKSGKSKGKDVNLAEFAVAAGDQMLYRSEDIQLDYKNNILKERAELAHSPLPAKYIDLDKGFRKENCK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BRK3-1; Sequence=Displayed; Name=2; IsoId=Q9BRK3-2; Sequence=VSP_027448, VSP_027449; Name=3; IsoId=Q9BRK3-3; Sequence=VSP_054528; Name=4; IsoId=Q9BRK3-4; Sequence=VSP_054529
Alternative Sequence
1..17; MALPSRILLWKLVLLQS -> MIRCAATG (in isoform 3); 25..125; Missing (in isoform 4); 407; L -> LASSPPT (in isoform 2); 435..442; GFRKENCK -> DPSGLCPLGA (in isoform 2)
3D Structural Models
Turn
66..68; 103..107; 142..144; 191..193; 237..241; 247..250; 277..280
Helix
57..59; 114..117; 129..131; 264..266
Beta Strand
36..39; 42..44; 50..52; 69..77; 86..95; 97..102; 108..110; 122..126; 133..140; 151..160; 170..180; 182..184; 204..209; 220..228; 242..245; 257..261; 268..275; 284..291
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
252..254; RGD
Domain (CC)
The RGD motif is involved in integrin ITGAV:ITGB3 binding.
Domain (FT)
29..157; Ig-like V-type 1; 160..288; Ig-like V-type 2
Region
294..318; Disordered