Protein detail
LZTS2
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Protein symbol LZTS2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1813LAPSER1
Gene Description
Leucine zipper tumor suppressor 2
Chromosome
10
Position
100996618-101007836
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificcervixBrain Regional Specificcerebral cortexCell SpecificEsophageal apical cellsBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionEnzyme inhibitor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LZTS2 | CSNK1D | P48730 | S | 224 | phosphorylation | PhosphoSite | |
| LZTS2 | CSNK1D | P48730 | S | 273 | phosphorylation | PhosphoSite | |
| LZTS2 | CSNK1D | P48730 | S | 220 | phosphorylation | PhosphoSite | |
| LZTS2 | CSNK1D | P48730 | S | 277 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KC1D | P48730 | LZTS2 | Q9BRK4 | Yes | No | No | PhosphoSite_norefProtMapperHuRIPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:33420362 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
669
Mass
72,759
Sequence
MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..25; Low complexity; 172..181; Polar residues; 187..199; Low complexity; 215..233; Polar residues; 241..251; Low complexity; 267..283; Low complexity; 284..295; Gly residues; 298..308; Polar residues; 311..320; Pro residues
Motif
631..640; Nuclear export signal
Coiled Coil
328..649
Region
1..332; Required for centrosomal localization; 1..56; Disordered; 92..131; Disordered; 150..201; Disordered; 215..323; Disordered; 447..669; Sufficient for interaction with CTNNB1; 450..669; Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing
Protein Families
LZTS2 family
Sequence Similarities
Belongs to the LZTS2 family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000061337ENSG00000099956ENSG00000100030ENSG00000101004ENSG00000105204ENSG00000105738ENSG00000116991ENSG00000130518ENSG00000131791ENSG00000134909ENSG00000137699ENSG00000139437ENSG00000141551ENSG00000146648ENSG00000157540ENSG00000158480ENSG00000171425ENSG00000175213ENSG00000175970ENSG00000181852ENSG00000182866
Interaction Count
21
Interaction Dataset
biogrid_opencellintact_biogridbiogrid_bioplex