Protein detail
RHG09
Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9)
Entry name RHG09 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9)
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificliverCell SpecificAdrenal medulla cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Immune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RHG09 | Q9BRR9 | RAC1 | P63000 | Yes | No | Yes | WangSIGNOR | SIGNOR:32203420 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryWestern blottingFlow cytometry | 9 | 315085003481790632795414289865853060870038321535400983464120109030760538 |
Sequence, Structure & Domains
Sequences
Length
750
Mass
83,260
Sequence
MLSSRWWPSSWGILGLGPRSPPRGSQLCALYAFTYTGADGQQVSLAEGDRFLLLRKTNSDWWLARRLEAPSTSRPIFVPAAYMIEESIPSQSPTTVIPGQLLWTPGPKLFHGSLEELSQALPSRAQASSEQPPPLPRKMCRSVSTDNLSPSLLKPFQEGPSGRSLSQEDLPSEASASTAGPQPLMSEPPVYCNLVDLRRCPRSPPPGPACPLLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRSETNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAPRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREAPTGRDQGSGDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLFP
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BRR9-1; Sequence=Displayed; Name=2; IsoId=Q9BRR9-2; Sequence=VSP_010325; Name=3; IsoId=Q9BRR9-3; Sequence=VSP_010340; Name=4; IsoId=Q9BRR9-4; Sequence=VSP_010340, VSP_010325; Name=5; IsoId=Q9BRR9-5; Sequence=VSP_010325, VSP_046391
Alternative Sequence
1..184; Missing (in isoform 3 and isoform 4); 438..456; Missing (in isoform 2, isoform 4 and isoform 5); 659..750; ALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLFP -> G (in isoform 5)
3D Structural Models
Turn
394..396
Helix
368..370; 420..439
Beta Strand
322..336; 346..361; 380..384; 389..392; 398..406; 412..416
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
163..180; Polar residues; 251..270; Polar residues; 291..300; Polar residues; 301..317; Low complexity; 446..462; Basic and acidic residues; 476..485; Acidic residues
Domain (CC)
A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.
Domain (FT)
22..88; SH3; 213..247; WW; 322..435; PH; 542..749; Rho-GAP
Region
120..187; Disordered; 242..319; Disordered; 342..345; Lipid binding; 397..399; Lipid binding; 432..669; Lipid binding; 446..488; Disordered
Clinical Relevance
Interaction Protein
ENSG00000177885
Interaction Count
1
Interaction Dataset
intact_biogrid