Protein detail

ZNG1A

Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6)

Entry name
ZNG1A
UniProt ID
Q9BRT8
EVMP confidence score
0.38
Supporting publications (n)
1
Transmembrane count
Protein classification
Disease related genesPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6)
Protein Class (2)
Disease related genesPredicted intracellular proteins
Protein Function (2)
  • Disease related genes
  • Predicted intracellular proteins
Ensembl
ENSG00000172785
Entrez Gene Symbol
ZNG1A
Gene Synonym
CBWD1
Gene Description
Zn regulated GTPase metalloprotein activator 1A
Chromosome
9
Position
120837-179147
Supporting publications (n)
1
EVMP confidence score
0.38
Function & Pathway5
Protein Function (2)
  • Disease related genes
  • Predicted intracellular proteins
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry22232942230646616
Sequence, Structure & Domains11

Sequences

Length
395
Mass
44,068
Sequence
MLPAVGSADEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTRFQEDQVCT
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BRT8-1; Sequence=Displayed; Name=2; IsoId=Q9BRT8-2; Sequence=VSP_019731, VSP_019732; Name=3; IsoId=Q9BRT8-3; Sequence=VSP_019734; Name=4; IsoId=Q9BRT8-4; Sequence=VSP_019733
Alternative Sequence
1..36; Missing (in isoform 2); 37..51; GLGAKIPVTIITGYL -> MYFKRAARAFPVLLT (in isoform 2); 114..395; Missing (in isoform 4); 236..254; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias
8..20; Acidic residues
Motif
17..24; psi-PxLVp motif; 107..110; CXCC motif
Domain (FT)
274..377; CobW C-terminal
Region
1..22; Disordered
Protein Families (2)
  • SIMIBI class G3E GTPase family
  • ZNG1 subfamily
Sequence Similarities
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Clinical Relevance1
Antibody (2)
HPA042759HPA042813
Supporting Publications1
PMIDTitleAbstract
36573687Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes.No abstract available