Protein detail
ZNF2
Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661)
Protein symbol ZNF2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTranscription factors |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661)
Protein Class
Predicted intracellular proteinsTranscription factors
Protein Function
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
Entrez Gene Symbol
Gene Synonym
A1-5Zfp661ZNF661
Gene Description
Zinc finger protein 2
Chromosome
2
Position
95165432-95184317
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specifichippocampal dentate gyrusBlood Cell SpecificneutrophilBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
95 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CHAMP1TRPM8TSKSUSP10USP15WAPLWBP11ZC3H13ZMYM2ZNF281 | Q14694Q5T200Q7Z2W7Q7Z5K2Q96JM3Q9UBW7Q9UJT2Q9Y2W2Q9Y2X9Q9Y4E8 | 0:0:0:0:0:0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_580 | ||
| ZNF223ZNF284ZNF714 | Q2VY69Q96N38Q9UK11 | 0:0:0 | hu.MAP2 | |||
| ZNF221ZNF225ZNF284 | Q2VY69Q9UK10Q9UK13 | 0:0:0 | hu.MAP2 | |||
| SCAND3ZNF232ZSCAN21ZSCAN23 | Q3MJ62Q6R2W3Q9UNY5Q9Y5A6 | 0:0:0:0 | hu.MAP2 | |||
| ANKS3ANKS6NEK8ZNF214ZNF669 | Q68DC2Q6ZW76Q86SG6Q96BR6Q9UL59 | 0:0:0:0:0 | hu.MAP2 | |||
| ANKS3ANKS6NEK8ZNF214 | Q68DC2Q6ZW76Q86SG6Q9UL59 | 0:0:0:0 | hu.MAP2 | |||
| SCAND3ZNF232 | Q6R2W3Q9UNY5 | 0:0 | hu.MAP2 | |||
| SCAND3ZKSCAN5ZNF232ZSCAN21 | Q6R2W3Q9UNY5Q9Y2L8Q9Y5A6 | 0:0:0:0 | hu.MAP2 | |||
| USP34ZNF214 | Q70CQ2Q9UL59 | 0:0 | hu.MAP2 | |||
| CHD5P3H2ZNF219 | Q8IVL5Q8TDI0Q9P2Y4 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Size Exclusion Chromatography | Flow cytometryMORPH | 1 | 41216884 |
Sequence, Structure & Domains
Sequences
Length
425
Mass
48,707
Sequence
MAAVSPTTRCQESVTFEDVAVVFTDEEWSRLVPIQRDLYKEVMLENYNSIVSLGLPVPQPDVIFQLKRGDKPWMVDLHGSEEREWPESVSLDWETKPEIHDASDKKSEGSLRECLGRQSPLCPKFEVHTPNGRMGTEKQSPSGETRKKSLSRDKGLRRRSALSREILTKERHQECSDCGKTFFDHSSLTRHQRTHTGEKPYDCRECGKAFSHRSSLSRHLMSHTGESPYECSVCSKAFFDRSSLTVHQRIHTGEKPFQCNECGKAFFDRSSLTRHQRIHTGESPYECHQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGDPRYQCNECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECTVCGKVFSSKSSVIQHQRRYAKQGID
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q9BSG1-2; Sequence=Displayed; Name=3; IsoId=Q9BSG1-3; Sequence=VSP_060238; Name=4; IsoId=Q9BSG1-4; Sequence=VSP_060237
Alternative Sequence
1..42; Missing (in isoform 3); 54..91; Missing (in isoform 4)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
93..110; Basic and acidic residues; 144..154; Basic and acidic residues
Zinc Finger
173..195; C2H2-type 1; 201..223; C2H2-type 2; 229..251; C2H2-type 3; 257..279; C2H2-type 4; 285..307; C2H2-type 5; 313..335; C2H2-type 6; 341..363; C2H2-type 7; 369..391; C2H2-type 8; 397..419; C2H2-type 9; degenerate
Domain (FT)
14..85; KRAB
Region
86..110; Disordered; 122..163; Disordered
Protein Families
Krueppel C2H2-type zinc-finger protein family
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000130726
Interaction Count
1
Interaction Dataset
biogrid_bioplex