Protein detail

UBAC1

Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2)

Entry name UBAC1	UniProt ID Q9BSL1	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000130560

Entrez Gene Symbol

UBAC1

Gene Synonym (3)

GBDR1KPC2UBADC1

Gene Description

UBA domain containing 1

Chromosome

Position

135932969-135961373

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificCardiomyocytes

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (3)

Biological Process (3)

Reactome (3)

Mediation Categories

Immune mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods	Mass spectrometry	15	34754007 38225453 38556629 10451508 40945317 40545963 37702715 26801919 27723984 30550287 38576002 40098346 38489029 40091455 34355211

Sequence, Structure & Domains12

Sequences

Length

405

Mass

45,338

Sequence

MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKMADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTEIFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BSL1-1; Sequence=Displayed; Name=2; IsoId=Q9BSL1-2; Sequence=VSP_062527

Alternative Sequence

1..102; Missing (in isoform 2)

3D Structural Models

Helix

194..203; 207..216; 221..230; 231..233

Beta Strand

189..191

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

108..120; Basic and acidic residues; 246..265; Low complexity

Domain (CC)

The UBA domains recognize and bind polyubiquitinated proteins.

Domain (FT)

14..98; Ubiquitin-like; 187..231; UBA 1; 288..328; UBA 2; 353..392; STI1

Region

101..120; Disordered; 235..271; Disordered

Clinical Relevance4

Antibody

HPA005651

Interaction Protein (3)

ENSG00000150991ENSG00000164068ENSG00000170315

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
39001700	Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available