Protein detail

CNPY3

Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein)

Entry name CNPY3	UniProt ID Q9BT09	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000137161

Entrez Gene Symbol

CNPY3

Gene Synonym (2)

CAG4ATNRC5

Gene Description

Canopy FGF signaling regulator 3

Chromosome

Position

42929480-42939294

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecifictestisCell SpecificLate spermatids

Function & Pathway7

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Cellular Component

GO:0005788 endoplasmic reticulum lumen

Molecular Function (2)

Biological Process (3)

Reactome (3)

Canonical Pathways (3)

M5883 Naba secreted factors
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Immune mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Olink Proximity Extension Assay；Mass Spectrometry	2	33709510 40098346

Sequence, Structure & Domains11

Sequences

Length

278

Mass

30,748

Sequence

MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRSSSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BT09-1; Sequence=Displayed; Name=2; IsoId=Q9BT09-2; Sequence=VSP_030132, VSP_030133

Alternative Sequence

51..54; VCKY -> GTCG (in isoform 2); 55..278; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

233..243; Low complexity

Coiled Coil

153..179

Domain (FT)

47..271; Saposin B-type

Region

215..278; Disordered

Protein Families

Canopy family

Sequence Similarities

Belongs to the canopy family.

Clinical Relevance2

Disease Involvement (2)

Disease variantEpilepsy

Antibody

HPA016560

Supporting Publications1

PMID	Title	Abstract
32218180	Proteomic Analysis of Blood Exosomes from Healthy Females and Breast Cancer Patients Reveals an Association between Different Exosomal Bioactivity on Non-tumorigenic Epithelial Cell and Breast Cancer Cell Migration in Vitro.	No abstract available