Protein detail
TBCD
Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)
Entry name TBCD | UniProt ID | EVMP confidence score 0.23 |
Supporting publications (n) 0 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)
Protein Class (5)
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Tubulin folding cofactor D
Chromosome
17
Position
82752042-82945914
Supporting publications (n)
0
EVMP confidence score
0.23
Fluorescence & Localization
Tissue SpecificbrainCell SpecificCone photoreceptor cells
Function & Pathway
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (4)
Biological Process (3)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence17
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | |||
| tight_junction | tight_junction | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| lateral_cell_membrane | plasma_membrane | UniProt_location |
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Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARL2-TBCD complex | ARL2TBCD | P36404Q9BTW9 | 0:0 | CORUM | CORUM:6455 | 2812690510831612 |
| MYL12BMYL6MYO18ATBCD | O14950O95411P60660Q9BTW9 | 0:0:0:0 | hu.MAP | |||
| MYL12BMYL6MYL6BTBCD | O14950P14649P60660Q9BTW9 | 0:0:0:0 | hu.MAP | |||
| MYL12BMYL6MYO18ATBCD | O14950P60660Q92614Q9BTW9 | 0:0:0:0 | hu.MAP | |||
| TARBP1TBCD | Q13395Q9BTW9 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 34771645 |
Sequence, Structure & Domains
Sequences
Length
1,192
Mass
132,600
Sequence
MALSDEPAAGGPEEEAEDETLAFGAALEAFGESAETRALLGRLREVHGGGAEREVALERFRVIMDKYQEQPHLLDPHLEWMMNLLLDIVQDQTSPASLVHLAFKFLYIITKVRGYKTFLRLFPHEVADVEPVLDLVTIQNPKDHEAWETRYMLLLWLSVTCLIPFDFSRLDGNLLTQPGQARMSIMDRILQIAESYLIVSDKARDAAAVLVSRFITRPDVKQSKMAEFLDWSLCNLARSSFQTMQGVITMDGTLQALAQIFKHGKREDCLPYAATVLRCLDGCRLPESNQTLLRKLGVKLVQRLGLTFLKPKVAAWRYQRGCRSLAANLQLLTQGQSEQKPLILTEDDDEDDDVPEGVERVIEQLLVGLKDKDTVVRWSAAKGIGRMAGRLPRALADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLVDVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIAAVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARALHNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMRQAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNPEEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMDDYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEKLFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNERVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLGVPRPQLVPQPGAC
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BTW9-1; Sequence=Displayed; Name=2; IsoId=Q9BTW9-2; Sequence=VSP_017210; Name=3; IsoId=Q9BTW9-3; Sequence=VSP_017211, VSP_017215, VSP_017213, VSP_017214; Name=4; IsoId=Q9BTW9-4; Sequence=VSP_017217, VSP_017218; Name=5; IsoId=Q9BTW9-5; Sequence=VSP_017212, VSP_017216
Alternative Sequence
1..1008; Missing (in isoform 2); 1..546; Missing (in isoform 3); 62..78; Missing (in isoform 5); 547..549; LVI -> MFN (in isoform 3); 662..697; LYDRQLYRGLGGQLMRQAVCVLIEKLSLSKMPFRGD -> PCICSWGLMSPESKAEFCVCVCRISLGRQCVHLSGL (in isoform 3); 698..1192; Missing (in isoform 3); 739..1156; Missing (in isoform 5); 1094; V -> VDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHGSAMPR (in isoform 4); 1182..1192; RPQLVPQPGAC -> SPTWCPAWCLLKPVLEPIPHPCLVRMSCS (in isoform 4)
Domain & Motif Annotations
Repeat
361..399; HEAT 1; 557..594; HEAT 2; 596..632; HEAT 3
Protein Families
TBCD family
Sequence Similarities
Belongs to the TBCD family.
Clinical Relevance
Disease Involvement (2)
Disease variantNeurodegeneration
Antibody
Interaction Protein
ENSG00000213465
Interaction Count
1
Interaction Dataset
intact_biogrid