Protein detail

MMTA2

Multiple myeloma tumor-associated protein 2 (hMMTAG2)

Entry name MMTA2	UniProt ID Q9BU76	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Multiple myeloma tumor-associated protein 2 (hMMTAG2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000143793

Entrez Gene Symbol

C1orf35

Gene Synonym (2)

MGC4174MMTAG2

Gene Description

Chromosome 1 open reading frame 35

Chromosome

Position

228100726-228105411

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Cell SpecificCone photoreceptor cellsSingle-Nuclei Brain Specificendothelial cellBlood Lineage SpecificmonocytesSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Reactome (2)

Mediation Categories

Immune mediation

Relations & Evidence1

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	1	41216884

Sequence, Structure & Domains7

Sequences

Length

263

Mass

29,412

Sequence

MFGSSRGGVRGGQDQFNWEDVKTDKQRENYLGNSLMAPVGRWQKGRDLTWYAKGRAPCAGPSREEELAAVREAEREALLAALGYKNVKKQPTGLSKEDFAEVCKREGGDPEEKGVDRLLGLGSASGSVGRVAMSREDKEAAKLGLSVFTHHRVESGGPGTSAASARRKPRAEDQTESSCESHRKSKKEKKKKKKRKHKKEKKKKDKEHRRPAEATSSPTSPERPRHHHHDSDSNSPCCKRRKRGHSGDRRSPSRRWHDRGSEA

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BU76-1; Sequence=Displayed; Name=2; IsoId=Q9BU76-2; Sequence=VSP_015129, VSP_015130; Name=3; IsoId=Q9BU76-3; Sequence=VSP_015131, VSP_015132; Name=4; IsoId=Q9BU76-4; Sequence=VSP_015133, VSP_015134

Alternative Sequence

125..141; SGSVGRVAMSREDKEAA -> RCGRVSRGGQHWARLLG (in isoform 2); 142..263; Missing (in isoform 2); 150..155; HHRVES -> VIPRPA (in isoform 3); 156..263; Missing (in isoform 3); 178..189; SCESHRKSKKEK -> RGVSRVTLEERS (in isoform 4); 190..263; Missing (in isoform 4)

Domain & Motif Annotations

Compositional Bias

1..11; Gly residues; 105..116; Basic and acidic residues; 117..132; Low complexity; 183..209; Basic residues

Region

1..21; Disordered; 105..132; Disordered; 148..263; Disordered

Clinical Relevance4

Antibody

HPA046175

Interaction Protein (4)

ENSG00000019995ENSG00000101266ENSG00000135250ENSG00000139767

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No abstract available