Protein detail

VAMP8

Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)

Entry name VAMP8	UniProt ID Q9BV40	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Transporter channels and pores
Predicted intracellular proteins

Transmembrane

76..96; Helical; Anchor for type IV membrane protein

Transmembrane Count

Ensembl

ENSG00000118640

Entrez Gene Symbol

VAMP8

Gene Synonym (2)

EDBVAMP-8

Gene Description

Vesicle associated membrane protein 8

Chromosome

Position

85561562-85582031

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function (2)

Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component (22)

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Molecular Function (4)

Biological Process (3)

KEGG (4)

Reactome (12)

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Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence34

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MARH9	Q86YJ5	VAMP8	Q9BV40	Yes	No	Yes	SIGNOR	SIGNOR:19457934

Protein Complex Composition (11)

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
SNARE complex (VAMP3VAMP4VAMP8STX6)	STX6 VAMP3 VAMP4 VAMP8	O43752 O75379 Q15836 Q9BV40	1:1:1:1	CompleatCORUM	CORUM:874Compleat:HC2251	11839770
SNARE complex (Vti1bStx7Stx8Vamp8)	STX12 STX7 STX8 VAMP8 VTI1B	O15400 Q86Y82 Q9BV40 Q9UEU0 Q9UNK0	1:1:1:1:1	Compleat	Compleat:HC5	15640147
SNARE complex STX17-SNAP47-VAMP8	SNAP47 STX17 VAMP8	P56962 Q5SQN1 Q9BV40	1:1:1	ComplexPortal		38534345 30655294 23217709 25686604 29790818 37848589 14755292 38182888
STX11-VAMP8 SNARE complex	STX11 STXBP2 VAMP8	O75558 Q15833 Q9BV40	0:0:0	SIGNOR	SIGNOR:SIGNOR-C273
STX17-VAMP8 SNARE complex	SNAP29 STX17 VAMP8	O95721 P56962 Q9BV40	2:1:1	SIGNORComplexPortalPDB	PDB:7BV6intact:EBI-59259545SIGNOR:SIGNOR-C551PDB:4WY4PDB:7bv6PDB:4wy4	38534345 32817423 23217709 25686604 29790818 37848589 14755292
	BET1L GOSR1 GOSR2 NAPA NSF SCFD1 SEC22B STX12 STX5 STX6 UBC USO1 VAMP8 VTI1B YKT6	O14653 O15498 O43752 O60763 O75396 O95249 P0CG48 P46459 P54920 Q13190 Q86Y82 Q8WVM8 Q9BV40 Q9NYM9 Q9UEU0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5845
	HSPA13 NAPA SDAD1 STX16 STX6 STX7 STX8 UBC VAMP3 VAMP4 VAMP8 VPS52 VPS53 VTI1A	O14662 O15400 O43752 O75379 P0CG48 P48723 P54920 Q15836 Q5VIR6 Q8N1B4 Q96AJ9 Q9BV40 Q9NVU7 Q9UNK0	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5855
	SNAP29 STX7 STXBP5 VAMP8	O15400 O95721 Q5T5C0 Q9BV40	0:0:0:0	hu.MAP
	OPTN STX10 STX12 VAMP8 VTI1A	O60499 Q86Y82 Q96AJ9 Q96CV9 Q9BV40	0:0:0:0:0	hu.MAP2
	SYPL1 VAMP2 VAMP8	P63027 Q16563 Q9BV40	0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass SpectrometryElisa	1	38071653

Sequence, Structure & Domains8

Sequences

Length

100

Mass

11,438

Sequence

MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVLICVIVFIIILFIVLFATGAFS

3D Structural Models

Helix

12..72

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

12..72; v-SNARE coiled-coil homology

Protein Families

Synaptobrevin family

Sequence Similarities

Belongs to the synaptobrevin family.

Clinical Relevance4

Antibody (4)

HPA006882 HPA007215 CAB037132 CAB037147

Interaction Protein (12)

ENSG00000049245ENSG00000079950ENSG00000092531ENSG00000099940ENSG00000103769ENSG00000105402ENSG00000117758ENSG00000135604ENSG00000135823ENSG00000136874ENSG00000170310ENSG00000183255

Interaction Count

Interaction Dataset (6)

biogrid_opencellintact_biogrid_opencellintact_biogrid_opencell_bioplexbiogrid_opencell_bioplexbiogrid_bioplexintact_biogrid

Supporting Publications1

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available