Protein detail
VAMP8
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Entry name VAMP8 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
76..96; Helical; Anchor for type IV membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
EDBVAMP-8
Gene Description
Vesicle associated membrane protein 8
Chromosome
2
Position
85561562-85582031
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
- GO:0005737 cytoplasm
- GO:0005765 lysosomal membrane
- GO:0005769 early endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0030667 secretory granule membrane
- GO:0030669 clathrin-coated endocytic vesicle membrane
- GO:0030670 phagocytic vesicle membrane
- GO:0031201 SNARE complex
- GO:0031901 early endosome membrane
- GO:0031902 late endosome membrane
- GO:0031982 vesicle
- GO:0035577 azurophil granule membrane
- GO:0035579 specific granule membrane
- GO:0042589 zymogen granule membrane
- GO:0048471 perinuclear region of cytoplasm
- GO:0055037 recycling endosome
- GO:0055038 recycling endosome membrane
- GO:0070062 extracellular exosome
- GO:0070821 tertiary granule membrane
- GO:0098594 mucin granule
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-432722 golgi associated vesicle biogenesis
- R-hsa-168249 innate immune system
- R-hsa-432720 lysosome vesicle biogenesis
- R-hsa-199991 membrane trafficking
- R-hsa-6798695 neutrophil degranulation
- R-hsa-199992 trans golgi network vesicle budding
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MARH9 | Q86YJ5 | VAMP8 | Q9BV40 | Yes | No | Yes | SIGNOR | SIGNOR:19457934 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass SpectrometryElisa | 1 | 38071653 |
Sequence, Structure & Domains
Sequences
Length
100
Mass
11,438
Sequence
MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVLICVIVFIIILFIVLFATGAFS
3D Structural Models
Helix
12..72
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
12..72; v-SNARE coiled-coil homology
Protein Families
Synaptobrevin family
Sequence Similarities
Belongs to the synaptobrevin family.
Clinical Relevance
Interaction Protein
ENSG00000049245ENSG00000079950ENSG00000092531ENSG00000099940ENSG00000103769ENSG00000105402ENSG00000117758ENSG00000135604ENSG00000135823ENSG00000136874ENSG00000170310ENSG00000183255
Interaction Count
12
Interaction Dataset
biogrid_opencellintact_biogrid_opencellintact_biogrid_opencell_bioplexbiogrid_opencell_bioplexbiogrid_bioplexintact_biogrid