Protein detail

TRAIP

E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)

Entry name TRAIP	UniProt ID Q9BWF2	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesEssential proteinsHuman disease related genesPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)

Protein Class (6)

Disease related genesEnzymesEssential proteinsHuman disease related genesPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Ensembl

ENSG00000183763

Entrez Gene Symbol

TRAIP

Gene Synonym (2)

RNF206TRIP

Gene Description

TRAF interacting protein

Chromosome

Position

49828601-49856574

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway6

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

Reactome (3)

Mediation Categories

Immune mediation

Relations & Evidence150

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (136)

136 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:P62979_P63279	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q9Y385	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P60604	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62253_P62987	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q13404	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q16763	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P62256	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_Q13404	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_Q96B02	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q5VVX9	TRAIP	Q9BWF2	Yes	Yes	No	SIGNOR	SIGNOR:34199813

Page 1 of 14Next

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:RING_E3	TRAIP UBB	P0CG47 Q9BWF2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	TRAIP UBC	P0CG48 Q9BWF2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RPS27A TRAIP	P62979 Q9BWF2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	TRAIP UBA52	P62987 Q9BWF2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
	CDV3 HAT1 HSPA4L TRAIP	O14929 O95757 Q9BWF2 Q9UKY7	0:0:0:0	hu.MAP
	CDC45 GINS1 GINS2 GINS3 GINS4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 TRAIP	O75419 P25205 P33991 P33992 P33993 P49736 Q14566 Q14691 Q9BRT9 Q9BRX5 Q9BWF2 Q9Y248	0:0:0:0:0:0:0:0:0:0:0:0	KEGG-MEDICUS
	PCNA TRAIP	P12004 Q9BWF2	3:2	PDB	PDB:4ztd
	PDSS2 TRAF2 TRAF3 TRAIP ZBTB41	Q12933 Q13114 Q5SVQ8 Q86YH6 Q9BWF2	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8288

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	39989284 40563475

Sequence, Structure & Domains11

Sequences

Length

469

Mass

53,294

Sequence

MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKRTIINKLFFDLAQEEENVLDAEFLKNELDNVRAQLSQKDKEKRDSQVIIDTLRDTLEERNATVVSLQQALGKAEMLCSTLKKQMKYLEQQQDETKQAQEEARRLRSKMKTMEQIELLLQSQRPEVEEMIRDMGVGQSAVEQLAVYCVSLKKEYENLKEARKASGEVADKLRKDLFSSRSKLQTVYSELDQAKLELKSAQKDLQSADKEIMSLKKKLTMLQETLNLPPVASETVDRLVLESPAPVEVNLKLRRPSFRDDIDLNATFDVDTPPARPSSSQHGYYEKLCLEKSHSPIQDVPKKICKGPRKESQLSLGGQSCAGEPDEELVGAFPIFVRNAILGQKQPKRPRSESSCSKDVVRTGFDGLGGRTKFIQPTDTVMIRPLPVKPKTKVKQRVRVKTVPSLFQAKLDTFLWS

3D Structural Models

Helix

463..465

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Motif

460..469; PIP-box

Coiled Coil

70..177; 201..280

Zinc Finger

7..50; RING-type

Region

211..469; Interaction with CYLD

Protein Families

TRAIP family

Sequence Similarities

Belongs to the TRAIP family.

Clinical Relevance2

Disease Involvement (3)

Disease variantDwarfismIntellectual disability

Antibody (2)

HPA036261 HPA036262

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available