Protein detail
BOC
Brother of CDO (Protein BOC)
Entry name BOC | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Brother of CDO (Protein BOC)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
856..876; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
BoiCDON2
Gene Description
BOC cell adhesion associated, oncogene regulated
Chromosome
3
Position
113211003-113287459
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificsalivary glandCell SpecificAstrocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function
Biological Process (3)
Reactome (6)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence61
Ligand-Receptor Signaling (54)
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | connectomeDB2020 | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes | ||||
| receptor | receptor | talklr | Yes | Yes | |||
| receptor | receptor | Cellinker | Yes | Yes | |||
| receptor | receptor | connectomeDB2020 | Yes | Yes | |||
| receptor | receptor | iTALK | Yes | Yes | |||
| receptor | receptor | Almen2009 | Yes | Yes |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BOC | Q9BWV1 | SHH | Q15465 | Yes | Yes | HPMRNetPathSignaLink3 | NetPath:16647304SignaLink3:23331499HPMR:17086203SignaLink3:16647304 |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PTCH2_BOC_transmembrane_receptor | BOCPTCH2 | Q9BWV1Q9Y6C5 | 1:1 | CellPhoneDB | CellPhoneDB:PTCH2_BOC_transmembrane_receptor | |
| BOCDHH | O43323Q9BWV1 | 2:2 | PDB | PDB:3n1g | ||
| BOCIHH | Q14623Q9BWV1 | 1:1 | PDB | PDB:3n1pPDB:3n1m | ||
| BOCDENND2CFBXO27HID1 | Q68D51Q8IV36Q8NI29Q9BWV1 | 0:0:0:0 | hu.MAP2 | |||
| BOCDENND2CHID1 | Q68D51Q8IV36Q9BWV1 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39996590 |
Sequence, Structure & Domains
Sequences
Length
1,114
Mass
121,059
Sequence
MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQRQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWCPQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BWV1-1; Sequence=Displayed; Name=2; IsoId=Q9BWV1-3; Sequence=VSP_034684
Alternative Sequence
514; K -> KQ (in isoform 2)
3D Structural Models
Helix
737..740; 760..762
Beta Strand
717..725; 728..734; 746..754; 764..769; 774..777; 785..794; 805..808
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
820..833; Pro residues; 972..986; Polar residues
Domain (FT)
36..123; Ig-like C2-type 1; 129..213; Ig-like C2-type 2; 235..315; Ig-like C2-type 3; 323..409; Ig-like C2-type 4; 474..571; Fibronectin type-III 1; 608..703; Fibronectin type-III 2; 712..812; Fibronectin type-III 3
Region
422..474; Disordered; 577..615; Disordered; 812..833; Disordered; 972..998; Disordered
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No related sentences available |