Protein detail

TM2D2

TM2 domain-containing protein 2 (Beta-amyloid-binding protein-like protein 1) (BBP-like protein 1)

Entry name
TM2D2
UniProt ID
Q9BX73
EVMP confidence score
0.28
Supporting publications (n)
4
Transmembrane count
2
Protein classification
Predicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
TM2 domain-containing protein 2 (Beta-amyloid-binding protein-like protein 1) (BBP-like protein 1)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
145..165; Helical; 183..203; Helical
Transmembrane Count
2
Ensembl
ENSG00000169490
Entrez Gene Symbol
TM2D2
Gene Synonym
BLP1
Gene Description
TM2 domain containing 2
Chromosome
8
Position
38988808-38996824
Supporting publications (n)
4
EVMP confidence score
0.28
Fluorescence & Localization
TM2D2 fluorescence
Tissue SpecificintestineCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specifichippocampal dentate gyrus
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
GO:0016020 membrane
Molecular Function
GO:0005515 protein binding
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence10

Ligand-Receptor Signaling (8)

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
transmembranetransmembrane_predictedPhobius

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
TM2D2TM2D3Q9BRN9Q9BX730:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion ChromatographyMass spectrometryMass spectrometry [LTQ-FT Ultra]134771645
Sequence, Structure & Domains

Sequences

Length
214
Mass
22,871
Sequence
MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAQPEGPGGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BX73-1; Sequence=Displayed; Name=2; IsoId=Q9BX73-2; Sequence=VSP_027495
Alternative Sequence
1..76; MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAQPEGPGGAASWEYGDPHSPVILCSYL -> MKKCLLPVLITCMQTAICKDRMMMIMILLVNYR (in isoform 2)

Domain & Motif Annotations

Domain (FT)
147..195; TM2
Region
40..59; Disordered
Protein Families
TM2 family
Sequence Similarities
Belongs to the TM2 family.
Clinical Relevance
Antibody (2)
HPA047152HPA050547
Supporting Publications4
PMIDTitleRelated sentences
31508500Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.No related sentences available
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No related sentences available
38225453Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available