Protein detail
PLVAP
Plasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1)
Protein symbol PLVAP | UniProt ID | EVMP score 0.50 |
Frequency 8 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Plasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
- Predicted intracellular proteins
Transmembrane
28..48; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FELSgp68PV-1PV1
Gene Description
Plasmalemma vesicle associated protein
Chromosome
19
Position
17351450-17377342
Frequency
8
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificAdipocytesSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M142 Pid ajdiss 2pathway
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
Page 3 of 3Previous
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Western BlottingMass SpectrometryElisa | 1 | 34771645 |
Sequence, Structure & Domains
Sequences
Length
442
Mass
50,594
Sequence
MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG
3D Structural Models
Domain & Motif Annotations
Compositional Bias
319..328; Basic and acidic residues
Coiled Coil
57..77; 202..225; 280..387
Region
301..328; Disordered; 394..418; Disordered
Clinical Relevance
Disease Involvement
Disease variant
Antibody